Network-targeted Theta-burst Stimulation for Episodic Memory Improvement in Mild Cognitive Impairment

Part of paid clinical trials in Los Angeles, California.

Sponsor
University of California, Los Angeles
Study ID
NCT04558164
Status
Recruiting
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Conditions

  • Cognitive Dysfunction
  • Memory Disorders in Old Age

Eligibility Criteria

Sex
ALL
Age
55 Years - 100 Years
Healthy Volunteers
Not accepted

Interventions

  • Active Theta Burst Stimulation — DEVICE
    Theta burst transcranial magnetic stimulation (TBS) will be delivered at 80-100% of motor threshold (MT).
  • Sham Theta Burst Stimulation — DEVICE
    Sham stimulation will be delivered at 0-10% of motor threshold (MT), with all other parameters matching the active TBS condition.

Study Details

The purpose of this study is to see if stimulation of the brain can improve memory. The investigators will use a device called transcranial magnetic stimulation that can stimulate and activate a specific part of the brain that is important for memory. The study will enroll MCI subjects and subjects with subjective memory complaints who will be randomly assigned to receive active or sham brain stimulation. 'Blinded' or 'sham-controlled' means that the subject will not know whether the treatment they receive is the active treatment or the non-active stimulation. In the 'sham' condition, the stimulator will turn on but will not actually be stimulating the target brain region.

Key Dates

Start date
Jan 26, 2021
Status verified
Apr 2026
Primary completion
May 30, 2026
Completion
Jun 30, 2026

Study Design

Enrollment
70 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Active TBS
    Theta burst stimulation (TBS) will be delivered at 100% of motor threshold (MT).
  • Sham Comparator: Sham TBS
    Sham stimulation will be delivered at 0% of motor threshold (MT), with all other parameters matching the active TBS condition.

Primary Outcome Measure

Verbal recall performance change [ Time Frame: Baseline: Day 2; During stimulation: Day 3, Day 7, Day 12, Day 17; Follow-up appointments: Day 18, Day 19, Day 20. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of California Los AngelesLos AngelesCalifornia90024
Sonja Hiller
[email protected]
310-210-6978

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By research site
University of California Los Angeles· Los Angeles, CA

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