Pain and Major Depressive Disorder

Part of paid clinical trials in Los Angeles, California.

Sponsor
University of California, Los Angeles
Study ID
NCT04556890
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 75 Years
Healthy Volunteers
Not accepted

Interventions

  • Active rTMS/Active iTBS DFPLC/Sham Pain M1 — DEVICE
    Active rTMS treatment for depression (600 pulses of active intermittent theta burst (iTBS) administrated at 120% MT to the left DLPFC) and sham treatment for pain at M1
  • Active rTMS/Active iTBS — DEVICE
    Active rTMS treatment for both, depression and pain (600 pulses of iTBS to left DLPFC followed by 600 iTBS + 1500 pulses of 10 Hz to M1

Study Details

This study will examine the effects of brain stimulation on pain symptoms associated with Major depressive disorder. This study will enroll 54 Subjects. Study subjects will be asked to complete surveys about their mood and well-being, 2 blood draws, 2 MRIs, 3 electroencephalograms, and receive 30 treatments of blinded transcranial magnetic stimulation. There is no control group as all subjects will receive some form of active treatment. Subjects are required to participate in 30-33 study visits and volunteer 40 hours of their time. Compensation for this study is $150 for completing all study activities.

Key Dates

Start date
Mar 1, 2023
Status verified
Sep 2025
Primary completion
Jun 30, 2027
Completion
Oct 31, 2027

Study Design

Enrollment
54 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Active rTMS/Active iTBS DFPLC/Sham Pain M1
  • Experimental: Active rTMS/Active iTBS

Primary Outcome Measure

Percent change in depression scores [ Time Frame: Through study completion, an average of 6 weeks ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
UCLA Semel InstituteLos AngelesCalifornia90024
THUC-DOAN NGO, BS
[email protected]
3108257797
Andrew F. Leuchter, MD (SUB_INVESTIGATOR)
Juliana Corlier, PhD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Los Angeles, CA

By condition
Depression
By specialty
PsychiatryMental healthBehavioral health
By research site
UCLA Semel Institute· Los Angeles, CA

Related Studies