Optical Coherence Tomography Angiography in Subjects With Retinal Vascular Disease

Part of paid clinical trials in Baltimore, Maryland.

Sponsor
Johns Hopkins University
Study ID
NCT04505618
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 99 Years
Healthy Volunteers
Accepted

Interventions

  • Swept-Source (SS) OCT Angiography — DEVICE
    Non-invasive, minimal risk, ocular imaging study
  • Spectral-Domain (SD) OCT Angiography — DEVICE
    Non-invasive, minimal risk, ocular imaging study
  • Fundus Imaging — DEVICE
    Non-invasive, minimal risk, ocular imaging study
  • Axial Length Measurement Device — DEVICE
    Non-invasive, minimal risk, ocular imaging study

Study Details

This study will perform a prospective, longitudinal analysis of clinical and imaging findings from normal controls and subjects with retinal vascular disease to better define the diagnostic imaging criteria that signify change in disease stage. This includes disease progression in early stages of disease or disease regression with appropriate standard-of-care treatment.

Key Dates

Start date
Oct 1, 2019
Status verified
Mar 2026
Primary completion
Jun 1, 2026
Completion
Sep 1, 2026

Study Design

Enrollment
1,050 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SCREENING

Arms

  • Other: Controls
    Subjects in this group do not have any ocular pathology and are also not hypertensive. Some subjects in this arm will undergo retinal vascular reactivity assessments.
  • Other: Diabetics with and without Diabetic Retinopathy Only
    Subjects in this group only have diabetes with or without diabetic retinopathy. Some subjects in this arm will undergo retinal vascular reactivity assessments.
  • Other: Hypertension Only
    Subjects in this group only have hypertension with or without ocular pathology related to hypertension. Some subjects in this arm may undergo retinal vascular reactivity assessments.
  • Other: Diabetics w/ or w/o Diabetic Retinopathy & Hypertension
    Subjects in this group have diabetes with or without diabetic retinopathy and hypertension with or without ocular pathology related to hypertension. Some subjects in this arm may undergo retinal vascular reactivity assessments.

Primary Outcome Measure

Correlation of Imaging [ Time Frame: 5 years ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Wilmer Eye InstituteBaltimoreMaryland21287
Ana Collazo Martinez
[email protected]
410-502-5052
C
Amir H Kashani, MD, PhD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Baltimore, MD

By condition
Diabetic retinopathy
By specialty
OphthalmologyRetina
By research site
Wilmer Eye Institute· Baltimore, MD

Related Studies