Gut Organoid and Microbiome Interactions in Hypertension

Part of paid clinical trials in Gainesville, Florida.

Sponsor
University of Florida
Study ID
NCT04497727
Status
Completed

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 80 Years
Healthy Volunteers
Accepted

Interventions

  • Gene Expression — OTHER
    Gene expression analysis of biopsy specimens obtained during routine colonoscopy examination

Study Details

The study compared basic properties of gut epithelia of hypertensive and normotensive reference subjects. The study determined if there are fundamental differences in the gut epithelium in hypertension compared to normotension. Specifically, this study examined gene expression profiles of gut organoids derived from biopsy samples of hypertensive and normotensive individuals undergoing clinically indicated colonoscopy.

Key Dates

Start date
Mar 5, 2021
Status verified
Aug 2025
Primary completion
Apr 8, 2022
Completion
Apr 21, 2024

Study Design

Enrollment
35 participants (actual)

Arms

  • Arm: Patients undergoing routine colonoscopy
    Participants were adults undergoing routine screening colonoscopy who met study eligibility criteria and provided written informed consent. Based on their blood pressure status, participants were categorized into two groups: individuals without hypertension (normotensive group) and individuals with high blood pressure (hypertensive group), defined according to the 2017 ACC/AHA guidelines

Primary Outcome Measure

Differential Gene Expression in Gut Epithelium [ Time Frame: At time of colonoscopy (single visit) ]

Locations (1)

FacilityCityStateZIPSite coordinators
University of FloridaGainesvilleFlorida32610-

Find similar trials in Gainesville, FL

By condition
Hypertension (high blood pressure)
By specialty
CardiologyHeart disease
By research site
University of Florida· Gainesville, FL

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