Measuring the Effects of Rhopressa on Episcleral and Retinal Blood Flow in Ocular Hypertension and Glaucoma Suspects

Part of paid clinical trials in Baltimore, Maryland.

Sponsor
University of Maryland, Baltimore
Study ID
NCT04401982
Status
Completed

Conditions

  • Ocular Hypertension
  • Suspect Glaucoma

Eligibility Criteria

Sex
ALL
Age
18 Years - 88 Years
Healthy Volunteers
Not accepted

Interventions

Study Details

Rhopressa effectively lowers intra-ocular pressure by improving conventional outflow and decreasing episcleral venous pressure. While this may result in improved episcleral venous flow, current methods to quantify episcleral blood flow in vivo are rudimentary and unable to accurately and precisely determine flow. Proof that Rhopressa effectively increases episcleral venous flow would differentiate it from other medications. Furthermore, this evidence could galvanize interest in the use of Rhopressa after popular Minimally Invasive Glaucoma Surgery (MIGS) procedures. In future studies, MIGS procedures could be used to improve the proximal outflow pathway, and Rhopressa to enhance distal outflow. Specific Aim: To determine the effect of Rhopressa on episcleral venous outflow and retinal blood flow in a cohort of treatment-naïve ocular hypertensive and glaucoma suspect patients. Hypothesis: Rhopressa increases episcleral venous flow and retinal blood flow from baseline at both 1 hour and 1 week after initiation of therapy.

Key Dates

Start date
Mar 15, 2021
Status verified
Mar 2022
Primary completion
Feb 22, 2022
Completion
Feb 22, 2022

Study Design

Enrollment
10 participants (actual)

Arms

  • Arm: Glaucoma Suspect
    Individuals with a diagnosis of glaucoma suspect

Primary Outcome Measure

Change in episcleral venous blood flow with Rhopressa [ Time Frame: 1 year ]

Locations (4)

FacilityCityStateZIPSite coordinators
University of Maryland Medical CenterBaltimoreMaryland21201-
University Physicians Inc.BaltimoreMaryland21201-
UM Faculty Physicians, Inc. | 5900 Waterloo CrossingColumbiaMaryland21045-
Maryland Eye Consultants and SurgeonsSilver SpringMaryland20902-

Find similar trials in Baltimore, MD

By research site
University of Maryland Medical Center· Baltimore, MDUniversity Physicians Inc.· Baltimore, MDUM Faculty Physicians, Inc. | 5900 Waterloo Crossing· Columbia, MDMaryland Eye Consultants and Surgeons· Silver Spring, MD

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