Metabolic Inflexibility is Related to Elevated Muscle Anaerobic Glycolysis

Conditions

• Metabolic Inflexibility

Eligibility Criteria

Sex

ALL

Age

18 Years - 50 Years

Healthy Volunteers

Not accepted

Interventions

• Weight loss surgery — PROCEDURE
  Severely obese women (BMI \>40) undergo sleeve gastrectomy

Study Details

The focus of this proposal is on overweight (25\>BMI\<30 kg/m2) subjects, as these individuals exhibit a high risk of becoming obese and/or developing metabolic diseases. We hypothesize that in some overweight individuals there is a "metabolic program" in skeletal muscle which predisposes them to the development of obesity. Findings may lead to clinical screening tools for determining risk for obesity in non-obese individuals and targeting this group for prevention.

Key Dates

Start date

Mar 3, 2020

Status verified

Aug 2025

Primary completion

Dec 31, 2025

Completion

Dec 31, 2025

Study Design

Enrollment

100 participants (estimated)

Arms

• Arm: Low oxidizers/high lactate
  Individuals with low aerobic oxidation
• Arm: High oxidizers/low lactate
  Individuals with high aerobic oxidation
• Arm: Obese
  Severely obese scheduled for surgery

Primary Outcome Measure

Carbohydrate/fat oxidation (RER) in the fasting condition. [ Time Frame: Years 1-5 ]

Central Contacts

• Terry Jones, PhD
  2527446249
  [email protected]
• Nicholas Broskey, PhD
  2527374684
  [email protected]

Locations (1)

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