Acute Exercise and the Cerebral Metabolic Response in Aging and Alzheimer's Disease

Part of paid clinical trials in Kansas City, Kansas.

Sponsor
University of Kansas Medical Center
Study ID
NCT04299308
Status
Completed

Conditions

Eligibility Criteria

Sex
ALL
Age
60 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Aerobic Exercise — BEHAVIORAL
    Participants will exercise for 15 minutes based on heart rate range. The study team will employ a stationary bike to maintain control over workload

Study Details

The overall goal is to characterize the acute exercise response as it relates to brain glucose metabolism in aging and Alzheimer's Disease (AD). The study team will also examine lactate metabolism, relationships with cognition, and the effect of exercise intensity.

Key Dates

Start date
Aug 28, 2020
Status verified
Jul 2025
Primary completion
Oct 31, 2023
Completion
Oct 31, 2023

Study Design

Enrollment
60 participants (actual)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Moderate Intensity Aerobic Exercise
    45-55% of heart rat reserve (HHR) Low range = ((Max HR from Visit 1) - Resting HR ) \* 0.45 + Resting HR High range = ((Max HR from Visit 1) - Resting HR) \* 0.55 + Resting HR
  • Experimental: High Intensity Aerobic Exercise
    65-75% of heart rat reserve (HHR) Low range = ((Max HR from Visit 1) - Resting HR ) \* 0.65 + Resting HR High range = ((Max HR from Visit 1) - Resting HR) \* 0.75 + Resting HR

Primary Outcome Measure

Fluorodeoxyglucose (FDG) Positron Emission Tomography (PET) Metabolism (Standard Uptake Value Ratio) [ Time Frame: Resting Vs acute exercise bout: ~1 month ]

Locations (1)

FacilityCityStateZIPSite coordinators
Univeristy of Kansas Medical CenterKansas CityKansas66160-

Find similar trials in Kansas City, KS

By condition
Alzheimer's disease
By specialty
NeurologyDementia careBrain disordersGeriatrics
By research site
Univeristy of Kansas Medical Center· Kansas City, KS

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