Study of Semaglutide for Non-Alcoholic Fatty Liver Disease (NAFLD), a Metabolic Syndrome With Insulin Resistance, Increased Hepatic Lipids, and Increased Cardiovascular Disease Risk (The SLIM LIVER Study)
Part of paid clinical trials in Birmingham, Alabama.
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
- Study ID
- NCT04216589
- Phase
- PHASE2
- Status
- Completed
Conditions
- HIV Infections
- Non-Alcoholic Fatty Liver Disease
Eligibility Criteria
- Sex
- ALL
- Age
- 18 Years - N/A
- Healthy Volunteers
- Not accepted
Interventions
- Semaglutide — DRUGAdministered subcutaneously
Study Details
The purpose of this study was to evaluate the effects of semaglutide on intra-hepatic triglyceride (IHTG) content in people living with HIV (PLWH), central adiposity, insulin resistance or pre-diabetes, and hepatic steatosis.
Key Dates
- Start date
- Feb 19, 2021
- Status verified
- Sep 2024
- Primary completion
- Mar 16, 2023
- Completion
- Sep 15, 2023
Study Design
- Enrollment
- 51 participants (actual)
- Allocation
- NA
- Intervention model
- SINGLE_GROUP
- Primary purpose
- TREATMENT
Arms
- Experimental: SemaglutideAll participants received a dose of 0.25 mg of semaglutide weekly starting at study entry, followed by 0.5 mg weekly starting at Week 2, and then 1.0 mg weekly from Weeks 4 through 24.
Primary Outcome Measure
Change (Absolute) in IHTG (%) [ Time Frame: Measured at pre-entry and Week 24 ]
Locations (8)
| Facility | City | State | ZIP | Site coordinators |
|---|---|---|---|---|
| Alabama CRS (Site ID: 31788) | Birmingham | Alabama | 35294 | - |
| University of Colorado Hospital CRS (Site ID: 6101) | Aurora | Colorado | 80045 | - |
| Johns Hopkins University CRS | Baltimore | Maryland | 21287 | - |
| Massachusetts General Hospital CRS (MGH CRS) (Site ID: 101) | Boston | Massachusetts | 02114 | - |
| Cincinnati Clinical Research Site (Site ID: 2401) | Cincinnati | Ohio | 45267-0405 | - |
| Ohio State University CRS (Site ID: 2301) | Columbus | Ohio | 43210 | - |
| Houston AIDS Research Team CRS (Site ID: 31473) | Houston | Texas | 77009 | - |
| University of Washington AIDS CRS (Site ID: 1401) | Seattle | Washington | 98104-9929 | - |
Find similar trials in Birmingham, AL
By condition
By specialty
By research site
Alabama CRS (Site ID: 31788)· Birmingham, ALUniversity of Colorado Hospital CRS (Site ID: 6101)· Aurora, COJohns Hopkins University CRS· Baltimore, MDMassachusetts General Hospital CRS (MGH CRS) (Site ID: 101)· Boston, MACincinnati Clinical Research Site (Site ID: 2401)· Cincinnati, OHOhio State University CRS (Site ID: 2301)· Columbus, OH
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