Treatment Results for Patients With Central Centrifugal Cicatricial Alopecia (CCCA): a Multicenter Prospective Study

Part of paid clinical trials in Winston-Salem, North Carolina.

Sponsor
Wake Forest University Health Sciences
Study ID
NCT04207931
Phase
PHASE4
Status
Recruiting
Apply to this trial

Conditions

  • Central Centrifugal Cicatricial Alopecia (CCCA)

Eligibility Criteria

Sex
FEMALE
Age
18 Years - 60 Years
Healthy Volunteers
Not accepted

Interventions

  • Topical steroid class I-II — DRUG
    applied once daily - 18 month duration of the study
  • Triamcinolone Acetonide — DRUG
    Intralesional Steroid Injection, 7.5mg/cc. max dose of 3 cc. Scalp injections will be administered every 6-8 weeks, for a total of 8 injections.
  • Doxycyline — DRUG
    oral antibiotic twice daily for 6 months
  • Minoxidil — DRUG
    5% solution or foam started after month 8

Study Details

The objective of this study is to examine photos of CCCA patients taken before and after treatment to compare treatment outcomes between different treatment groups

Key Dates

Start date
Apr 30, 2018
Status verified
Mar 2026
Primary completion
Nov 30, 2026
Completion
Mar 31, 2027

Study Design

Enrollment
250 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Active Comparator: Topical steroid plus oral antibiotic group
    Participants in this group receive topical steroid (class I-II applied once daily) plus oral antibiotic group (doxycyline 100 mg twice daily for 6 months), and then topical minoxidil (5% solution or foam) after 8 months of treatment.
  • Active Comparator: Topical steroid plus intralesional steroid injection group
    Participants in this group receive topical steroid (class I-II applied once daily) plus intralesional steroid group (7.5mg/cc of kenaolog, max dose of 3 cc), and then topical minoxidil (5% solution or foam) after 8 months of treatment

Primary Outcome Measure

Central Scalp Alopecia Photographic Scale in African American Women [ Time Frame: baseline ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Wake Forest Baptist Health Department of DermatologyWinston-SalemNorth Carolina27157-

Find similar trials in Winston-Salem, NC

By research site
Wake Forest Baptist Health Department of Dermatology· Winston-Salem, NC