LITT Followed by Hypofractionated RT for Recurrent Gliomas

Part of paid clinical trials in Baltimore, Maryland.

Sponsor
University of Maryland, Baltimore
Study ID
NCT04181684
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
22 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Procedure: LITT — DEVICE
    This procedure is done under MRI guidance and employs low-powered thermal energy to achieve tumor ablation through coagulation.
  • Hypo-Fractionated Radiation Therapy — RADIATION
    Treatments will be delivered once daily on consecutive treatment days (typically 5 fractions per week). Radiation therapy simulation is to be performed within 10 days of the LITT procedure.

Study Details

The purpose of this study is to evaluate the treatment regimen of using Laser Interstitial Thermal Therapy (LITT) and Hypo-fractionated Radiation Therapy to treat patients with recurrent gliomas.

Key Dates

Start date
Jan 8, 2020
Status verified
Jan 2026
Primary completion
Dec 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
32 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Experimental: LITT with Hypofractionated radiation therapy
    Laser interstitial thermal therapy (LITT) followed by hypo-fractionated radiation therapy, 35Gy/10 fractions.

Primary Outcome Measure

Adverse Events [ Time Frame: 2 years ]

Central Contacts

Locations (4)

FacilityCityStateZIPSite coordinators
University of Maryland Greenebaum Cancer CenterBaltimoreMaryland21201
Mark Mishra, MD
410-328-6080
Megan Camara
410-369-5226
Graeme Woodworth, MD (SUB_INVESTIGATOR)
UCH Kaufman Cancer CenterBel AirMaryland21014
Mark Mishra, MD
410-328-6080
Caitlin Eggleston
[email protected]
Central Maryland Radiation OncologyColumbiaMaryland21044
Mark Mishra, MD
410-328-6080
Caitlin Eggleston
[email protected]
Baltimore Washington Medical CenterGlen BurnieMaryland21061
Mark Mishra, MD
410-328-6080
Pilar Strycula
[email protected]

Find similar trials in Baltimore, MD

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By specialty
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By research site
University of Maryland Greenebaum Cancer Center· Baltimore, MDUCH Kaufman Cancer Center· Bel Air, MDCentral Maryland Radiation Oncology· Columbia, MDBaltimore Washington Medical Center· Glen Burnie, MD

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