Primary Sclerosing Cholangitis in Children

Conditions

• Cholangitis, Sclerosing
• Liver Diseases
• Primary Sclerosing Cholangitis

Eligibility Criteria

Sex

ALL

Age

2 Years - 25 Years

Healthy Volunteers

Not accepted

Study Details

Primary sclerosing cholangitis (PSC) is a rare liver disease that damages the liver's bile ducts. Bile ducts are tiny tubes that carry bile from the liver to the small intestine. Bile is a liquid produced by the liver that helps us absorb and use the nutrients in the food we eat. In people with PSC, the bile backs up into the liver and will damage it, causing scarring of the liver. The purposes of this study are to: * Collect medical and other data to learn more about PSC, how it progresses, and identify factors that may cause the disease to progress more quickly. * Ask questions about how PSC symptoms affect your child's life to learn more about its impact on your child's daily functioning * Children with PSC who are seen at one of the participating clinical sites in the Childhood Liver Disease Research Network (ChiLDReN) will be asked to contribute information, DNA, and other specimens. The information and specimens will be available to investigators to carry out approved research aimed at learning more about the possible causes and long-term effects of PSC.

Key Dates

Start date

Dec 30, 2021

Status verified

Jun 2026

Primary completion

May 31, 2029

Completion

May 31, 2029

Study Design

Enrollment

1,000 participants (estimated)

Primary Outcome Measure

To characterize the major phenotypes of PSC including patients with large duct or small duct disease, with and without Inflammatory Bowel Disease (IBD), and with and without Auto Immune Hepatitis (AIH) [ Time Frame: up to 10 years ]

Central Contacts

• Melissa Sexton, BBA, CCRP
  734-693--3811
  [email protected]
• Melissa Sexton, BBA, CCRP
  734-693-3811
  [email protected]

Locations (11)

Find similar trials in Los Angeles, CA

Related Studies

• DILIN - Prospective Study
  Recruiting · Duke University · Los Angeles, California
• Treating Primary Sclerosing Cholangitis and Biliary Atresia With Vancomycin
  PHASE1 · Recruiting · Sacramento Pediatric Gastroenterology · Sacramento, California
• MRI Based Biomarkers in Pediatric Autoimmune Liver Disease
  Recruiting · Children's Hospital Medical Center, Cincinnati · Cincinnati, Ohio
• MRI Biomarkers in as Predictor of Clinical Endpoints in Pediatric Autoimmune Liver Disease
  Recruiting · Children's Hospital Medical Center, Cincinnati · Cincinnati, Ohio