Expression Profiles of Integrin αDβ2 on Neutrophils in Sepsis

Part of paid clinical trials in Boston, Massachusetts.

Sponsor
Boston Children's Hospital
Study ID
NCT04103281
Status
Recruiting
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Conditions

  • Sepsis

Eligibility Criteria

Sex
ALL
Age
2 Years - 50 Years
Healthy Volunteers
Not accepted

Interventions

  • Sepsis — OTHER
    Sepsis patients in the ICU with a breathing tube

Study Details

In this research study we want to learn more about the characteristics of neutrophils that are present in the blood and secretions from a breathing tube of patients with sepsis. Sepsis is a severe type of infection, affecting various parts of the body. Neutrophils are a type of white blood cell that are part of the body's immune system. Even though neutrophils are important in getting rid of germs, they also may be harmful to parts of the body by causing injury in the lungs in patients with sepsis. Neutrophils can change their character in sepsis. Because of this, it is important for doctors to know what kind of neutrophils are in the blood and secretions from the breathing tube of patients with sepsis so that they can work to develop therapies to prevent these cells from being harmful.

Key Dates

Start date
Sep 1, 2020
Status verified
Mar 2026
Primary completion
Jun 1, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
75 participants (estimated)

Arms

  • Arm: Sepsis Patients
  • Arm: Control Patients

Primary Outcome Measure

Neutrophil characteristics [ Time Frame: One day ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Boston Children's HospitalBostonMassachusetts02115
Koichi Yuki, MD
[email protected]
617-355-6225

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By research site
Boston Children's Hospital· Boston, MA

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