Mechanisms Underlying the Protective Vascular Effects of Dietary Potassium in Humans

Part of paid clinical trials in Newark, Delaware.

Sponsor
University of Delaware
Study ID
NCT04101188
Status
Recruiting
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Conditions

  • Cardiovascular Risk Factor

Eligibility Criteria

Sex
ALL
Age
18 Years - 45 Years
Healthy Volunteers
Accepted

Interventions

  • Moderate Potassium/Low Sodium Diet — OTHER
    Consumption of 10 days of a diet moderate in potassium and low in sodium.
  • Moderate Potassium/High Sodium Diet — OTHER
    Consumption of 10 days of a diet moderate in potassium and high in sodium.
  • High Potassium/High Sodium Diet — OTHER
    Consumption of 10 days of a diet high in potassium and high in sodium.

Study Details

Americans continue to consume high amounts of sodium. Potassium is notable for its blood pressure lowering effects but less is known regarding its effect on the vasculature. This investigation seeks to determine the role of dietary potassium on the vasculature in the presence of a high sodium diet in salt-resistant adults.

Key Dates

Start date
Jan 16, 2020
Status verified
Mar 2026
Primary completion
Jul 31, 2026
Completion
Jul 31, 2026

Study Design

Enrollment
90 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION

Arms

  • Experimental: Moderate Potassium/Low Sodium
    Subjects will be provided with a diet that is moderate in potassium and low in sodium.
  • Experimental: Moderate Potassium/High Sodium
    Subjects will be provided with a diet that is moderate in potassium and high in sodium.
  • Experimental: High Potassium/High Sodium
    Subjects will be provided with a diet that is high in both potassium and sodium.

Primary Outcome Measure

Conduit artery endothelial-dependent dilation [ Time Frame: on day 10 of the diet ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of DelawareNewarkDelaware19716
Shannon L Lennon, PHD
[email protected]
302-831-2798

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By research site
University of Delaware· Newark, DE

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