Exparel Injection Effect on Postoperative Opioid Usage

Part of paid clinical trials in Columbia, Missouri.

Sponsor
University of Missouri-Columbia
Study ID
NCT04085913
Phase
EARLY_PHASE1
Status
Enrolling By Invitation

Conditions

  • Parathyroid Adenoma
  • Thyroid

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Lidocaine Epinephrine — DRUG
    Preincision injection, as is current practice
  • Bupivacaine Hydrochloride-EPINEPHrine — DRUG
    Preincision injection
  • Lidocaine Epinephrine, Bupivacaine Hydrochloride-EPINEPHrine — DRUG
    Preincison injection of lidocaine and epinephrine and a postincision injection of Exparel

Study Details

The question proposed by this study, is one of patient outcomes. Does intraoperative injection of Exparel decrease postoperative use of opioid pain medications in patients undergoing thyroid and parathyroid surgery? The trial seeks to assess the effect that Exparel has on postoperative pain control.

Key Dates

Start date
Sep 30, 2019
Status verified
Jul 2024
Primary completion
Jun 6, 2024
Completion
Jul 31, 2025

Study Design

Enrollment
100 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT

Arms

  • Active Comparator: Current Practice
    Thyroid or parathyroid surgery with local injection of lidocaine and epinephrine preincision, as is current practice.
  • Experimental: Bupivicaine HCL
    Thyroid or parathyroid surgery with local injection of bupivicaine HCL and Epinephrine preincision.
  • Experimental: Exparel Injection
    Thyroid and parathyroid surgery with local injection of lidocaine and epinephrine preincison and Exparel postincision

Primary Outcome Measure

Incidence of opioid use when given Exparel intraoperatively [ Time Frame: After surgery, patients will be monitored for two weeks, until they return for their first postoperative appointment. ]

Locations (1)

FacilityCityStateZIPSite coordinators
University of MissouriColumbiaMissouri65212-

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By research site
University of Missouri· Columbia, MO

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