Uric Acid, Klotho and Salt Sensitivity in Young Adults Born Preterm

Conditions

Allopurinol — DRUG
Study Part 2- Preterm group only: After Visit 5 preterm born participants will start allopurinol 200 mg daily PO for 6 weeks. The 1 week high and low salt diets and assessments will be repeated while on allopurinol.
Dietary Intervention — OTHER
High-Na+ (250 mmol/d) and low-Na+ (50 mmol/d) standard isocaloric K+ diets (75 mmol/1000 kcal/d) for 1 week each as 3 meals and 1 snack a day provided by the Clinical Research Unit Metabolic Kitchen. Part 2 preterm only- the diets will be repeated while the participant is taking allopurinol.

The purpose of this research is to learn about how salt in the diet influences blood pressure in young adults who were born prematurely.

Experimental: Preterm Group
Subjects with very low birth weight (\<37 completed weeks' gestation and birth weight \<1500 g) will receive a dietary intervention (high/low salt diet) and FDA approved drug, Allopurinol
Active Comparator: Term-born control group
Subjects with birth weight ≥2500 g will receive a dietary intervention (high/low salt diet)

Proportion with salt sensitivity of blood pressure at baseline via ABPM [ Time Frame: Day 7 to 14 ]

Facility	City	State	ZIP	Site coordinators
Wake Forest University Health Sciences	Winston-Salem	North Carolina	27157	Hossam Shaltout, PhD [email protected] 336-716-1251 Hossam Shaltout, PhD (PRINCIPAL_INVESTIGATOR) Andrew South, MD, MS (SUB_INVESTIGATOR)

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