Myeloid-Derived Suppressor Cell Function in Breast Cancer Patients

Part of paid clinical trials in Columbus, Ohio.

Sponsor
Ohio State University Comprehensive Cancer Center
Study ID
NCT04022616
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
FEMALE
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Specimen collection — OTHER
    Specimens are obtained from patients who are being treated for breast malignancies.

Study Details

Myeloid-Derived Suppressor Cell Function in Breast Cancer Patients

Key Dates

Start date
Jun 4, 2010
Status verified
Apr 2026
Primary completion
Dec 31, 2027
Completion
Dec 31, 2027

Study Design

Enrollment
99 participants (estimated)

Arms

  • Arm: Immediate Surgery
    Adult patients with breast malignancy.
  • Arm: Neo-adjuvant Chemotherapy
    Adult patients with biopsy proven operable breast cancer who in the opinion of treating physician are suited to receive neo-adjuvant chemotherapy.
  • Arm: Lymph Node Tissue
    Adult patients with breast malignancy who will be having a primary lymph node removed during breast surgery.
  • Arm: Metastatic Breast Cancer
    Adult patients with biopsy proven stage IV breast cancer who are starting a new line palliative systemic therapy. A palliative systemic therapy will be defined in this trial as any chemotherapy regimen or combination of endocrine therapy with targeted agents such as cyclin dependent kinase 4/6 (CDK 4/6) inhibitors, HER2 targeting agents or inhibitors of mammalian target of rapamycin (mTOR).

Primary Outcome Measure

Isolate unfavorable immune cells MDSC from the peripheral blood or tumors of study subjects and test how strongly they inhibit function of favorable immune cells called Natural Killer Cells. [ Time Frame: up to 1 year ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Ohio State University Comprehensive Cancer CenterColumbusOhio43210-

Find similar trials in Columbus, OH

By condition
Breast cancer
By specialty
OncologyBreast oncologyWomen's health
By research site
Ohio State University Comprehensive Cancer Center· Columbus, OH

Related Studies