A Study of Tirzepatide (LY3298176) Versus Semaglutide Once Weekly as Add-on Therapy to Metformin in Participants With Type 2 Diabetes

Part of paid clinical trials in Birmingham, Alabama.

Sponsor
Eli Lilly and Company
Study ID
NCT03987919
Phase
PHASE3
Status
Completed

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

Study Details

The reason for this study is to compare the effect of the study drug tirzepatide to semaglutide on blood sugar levels in participants with type 2 diabetes. The study will last approximately 47 weeks and may include about 12 visits.

Key Dates

Start date
Jul 30, 2019
Status verified
Jul 2021
Primary completion
Jan 28, 2021
Completion
Feb 15, 2021

Study Design

Enrollment
1,879 participants (actual)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: 5 mg Tirzepatide
    5 milligrams (mg) tirzepatide administered subcutaneously (SC) once a week.
  • Experimental: 10 mg Tirzepatide
    10 mg tirzepatide administered SC once a week.
  • Experimental: 15 mg Tirzepatide
    15 mg tirzepatide administered SC once a week.
  • Active Comparator: 1 mg Semaglutide
    1 mg semaglutide administered SC once a week.

Primary Outcome Measure

Change From Baseline in Hemoglobin A1c (HbA1c) (10 mg and 15 mg) [ Time Frame: Baseline, Week 40 ]

Locations (51)

FacilityCityStateZIPSite coordinators
Cahaba ResearchBirminghamAlabama35242-
Syed Research Consultants LlcSheffieldAlabama35660-
National Research Institute - Huntington ParkHuntington ParkCalifornia90255-
Catalina Research Institute, LLCMontclairCalifornia91763-
Valley Clinical Trials, Inc.NorthridgeCalifornia91325-
National Research Institute - Huntington ParkPanorama CityCalifornia91402-
Artemis Institute for Clinical ResearchRiversideCalifornia92503-
Artemis Institute for Clinical ResearchSan DiegoCalifornia92103-
Artemis Institute for Clinical ResearchSan MarcosCalifornia92078-
University Clinical Investigators, Inc.TustinCalifornia92780-
CMR of Greater New HavenHamdenConnecticut06517-
Clinical Research of South FloridaCoral GablesFlorida33134-
East Coast Institute for Research at The Jones CenterLake CityFlorida32055-
South Florida Clinical Research InstituteMargateFlorida33063-
New Horizon Research CenterMiamiFlorida33165 3338-
Suncoast Research GroupMiamiFlorida33135-
Oviedo Medical ResearchOviedoFlorida32765-
South Broward ResearchPembroke PinesFlorida33027-
United Osteoporosis CenterGainesvilleGeorgia30501-
Sky Clinical Research NetworkUnion CityGeorgia30291-
Elite Clinical TrialsBlackfootIdaho83221-
University of Iowa Hospital & ClinicIowa CityIowa52242-
Cotton O'Neil ClinicTopekaKansas66606-
Cotton O'Neil Diabetes and Endocrinology CenterTopekaKansas66606-
NECCR PrimaCare ResearchFall RiverMassachusetts02721-
ActivMed Practices and ResearchMethuenMassachusetts01844-
Olive Branch Family Medical CenterOlive BranchMississippi38654-
Clinvest Research LLCSpringfieldMissouri65810-
Premier ResearchTrentonNew Jersey08611-
Albany Medical College, Division of Community EndocrinologyAlbanyNew York12206-
PharmQuestGreensboroNorth Carolina27408-
Diabetes & Endocrinology Consultants, PCMorehead CityNorth Carolina28557-
PMG Research of WilmingtonWilmingtonNorth Carolina28401-
Lillestol Research LLCFargoNorth Dakota58104-
Aventiv Research IncColumbusOhio43213-
Intend Research, LLCNormanOklahoma73069-
Heritage Valley Medical Group, Inc.BeaverPennsylvania15009-
Capital Area Research, LLCCamp HillPennsylvania17011-
Detweiler Family Medicine & AssociatesLansdalePennsylvania19446-
Green & Seidner Family Practice AssociatesLansdalePennsylvania19446-
Thomas Jefferson UniversityPhiladelphiaPennsylvania19107-
Preferred Primary Care Physicians, Preferred Clinical Research-St. ClairPittsburghPennsylvania15243-
Holston Medical GroupBristolTennessee37620-
Dallas Diabetes Research CenterDallasTexas75230-
Biopharma Informatic, Inc.HoustonTexas77043-
Consano Clinical Research, LLCShavano ParkTexas78231-
Carl R. Meisner Medical Clinic, PLLCSugar LandTexas77478-
Martin Diagnostic ClinicTomballTexas77375-
Burke Internal Medicine and ResearchBurkeVirginia22015-
Capital Clinical Research CenterOlympiaWashington98502-
The Vancouver ClinicVancouverWashington98664-

Find similar trials in Birmingham, AL

By condition
Type 2 diabetes
By specialty
EndocrinologyMetabolic healthWeight loss
By research site
Cahaba Research· Birmingham, ALSyed Research Consultants Llc· Sheffield, ALNational Research Institute - Huntington Park· Huntington Park, CACatalina Research Institute, LLC· Montclair, CAValley Clinical Trials, Inc.· Northridge, CANational Research Institute - Huntington Park· Panorama City, CA

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