Discovering New Genetic Markers in Adults and Children Who May Be At Risk for Hereditary Forms of Cancer

Part of paid clinical trials in Basking Ridge, New Jersey.

Sponsor
Memorial Sloan Kettering Cancer Center
Study ID
NCT03922893
Status
Recruiting
Apply to this trial

Conditions

  • Cancer

Eligibility Criteria

Sex
ALL
Age
N/A - N/A
Healthy Volunteers
Accepted

Interventions

  • Family History Information — OTHER
    The family history ascertainment focuses on self-reported family history of first-, second-, and third-degree family members, including types of malignancies/ pre-malignant lesions and age at diagnosis.
  • ORAGENE — GENETIC
    Approximately 2-4mL of saliva may be collected in specialized Oragene DNA Self-Collection Kit tubes or buccal swab-based collection devices.
  • Blood — GENETIC
    For select participants, 1-2 tubes of blood will be drawn for DNA and RNA analysis
  • Skin Biopsy — OTHER
    In certain circumstances, for Memorial Sloan Kettering participants and their family members, it may be necessary to obtain a skin biopsy.

Study Details

This study is being done to attempt to identify genetic mutations or other gene-based variations in adults and children who have cancer, or are likely to develop an inherited form of cancer, and potentially reduce their risk for cancer or treat the cancer earlier.

Key Dates

Start date
Apr 17, 2019
Status verified
Dec 2025
Primary completion
Apr 30, 2029
Completion
Apr 30, 2029

Study Design

Enrollment
1,500 participants (estimated)

Arms

  • Arm: Proband
    First individual in a family to consent to this protocol
  • Arm: Family Member Participants
    Family members of the proband will be approached to consent to this protocol

Primary Outcome Measure

Discovery of novel cancer susceptibility genes [ Time Frame: Up to 10 years ]

Central Contacts

Locations (7)

FacilityCityStateZIPSite coordinators
Memorial Sloan Kettering Basking Ridge (Consent only)Basking RidgeNew Jersey07920
Kenneth Offit, MD, MPH
646-888-4059
Memorial Sloan Kettering Monmouth (Consent only)MiddletownNew Jersey07748
Kenneth Offit, MD, MPH
646-888-4059
Memorial Sloan Kettering Bergen (Consent only )MontvaleNew Jersey07645
Kenneth Offit, MD, MPH
646-888-4059
Memorial Sloan Kettering Cancer Center @ Commack (Consent Only)CommackNew York11725
Kenneth Offit, MD, MPH
646-888-4059
Memorial Sloan Kettering Westchester (Consent only)HarrisonNew York10604
Kenneth Offit, MD, MPH
646-888-4059
Memorial Sloan Kettering Cancer CenterNew YorkNew York10065
Kenneth Offit, MD, MPH
646-888-4059
Memorial Sloan Kettering Nassau (Consent only)UniondaleNew York11553
Kenneth Offit, MD, MPH
646-888-4059

Find similar trials in Basking Ridge, NJ

By research site
Memorial Sloan Kettering Basking Ridge (Consent only)· Basking Ridge, NJMemorial Sloan Kettering Monmouth (Consent only)· Middletown, NJMemorial Sloan Kettering Bergen (Consent only )· Montvale, NJMemorial Sloan Kettering Cancer Center @ Commack (Consent Only)· Commack, NYMemorial Sloan Kettering Westchester (Consent only)· Harrison, NYMemorial Sloan Kettering Cancer Center· New York, NY

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