Effect of Exercise and/or Liraglutide on Vascular Dysfunction and Insulin Sensitivity in Type 2 Diabetes ( ZQL007)

Part of paid clinical trials in Charlottesville, Virginia.

Sponsor
University of Virginia
Study ID
NCT03883412
Phase
PHASE4
Status
Unknown

Conditions

  • Type2 Diabetes

Eligibility Criteria

Sex
ALL
Age
21 Years - 60 Years
Healthy Volunteers
Accepted

Interventions

  • Exercise — OTHER
    16 weeks of treatment
  • Liraglutide — DRUG
    16 weeks of Liraglutide

Study Details

The primary objective of this study is to examine whether exercise training alone, liraglutide treatment alone or exercise training plus liraglutide treatment increases cardiac and muscle capillary blood volume, improves vascular function in the larger conduit vessels, and enhances insulin's metabolic action in humans with Type 2 diabetes. Subjects will be randomized to one of the three groups: exercise training, liraglutide treatment, and exercise + liraglutide. They will be studied at the baseline and then after 16 weeks of intervention.

Key Dates

Start date
Feb 28, 2019
Status verified
Dec 2023
Primary completion
Jun 30, 2025
Completion
Dec 31, 2025

Study Design

Enrollment
60 participants (estimated)
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
TREATMENT

Arms

  • Experimental: Exercise Alone
    16 weeks of treatment
  • Experimental: Liraglutide alone
    16 weeks of treatment
  • Experimental: Exercise + Liraglutide
    16 weeks of treatment

Primary Outcome Measure

Microvascular Blood Volume - change from baseline [ Time Frame: 16 weeks ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of VirginiaCharlottesvilleVirginia22906
Zhenqi Liu, MD
[email protected]
434-243-2603
Eugene Barrett, MD, PhD
[email protected]
434-924-1175

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By research site
University of Virginia· Charlottesville, VA

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