A Causative Role for Amylin in Diabetic Peripheral Neuropathy

Part of paid clinical trials in Lexington, Kentucky.

Sponsor
Zabeen Mahuwala, MD
Study ID
NCT03481283
Status
Recruiting
Apply to this trial

Conditions

  • Peripheral Neuropathy
  • Type2 Diabetes

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Study Details

Three pieces of information lead to the basis for this study: 1. Individuals with Type-2 diabetes commonly develop peripheral neuropathy. 2. Increased production of the hormone amylin occurs in individuals who have Type-2 diabetes. 3. Aggregations of amylin was found in the peripheral vasculature of rats that overexpressed human amylin. The purpose of this study is to determine whether a correlation exists between the amount of amylin present in the upper extremities of human subjects with Type-2 diabetes and the extent to which symptoms of peripheral neuropathy are expressed in those subjects. The investigators will be testing this by initially collecting blood and skin biopsy samples from subjects, followed by measuring patient sensation and pain responses to heat, cold, and pressure in the upper extremities.

Key Dates

Start date
Feb 5, 2018
Status verified
Jan 2026
Primary completion
Jan 31, 2029
Completion
Jan 31, 2029

Study Design

Enrollment
40 participants (estimated)

Primary Outcome Measure

Red blood cell amylin level vs severity of peripheral neuropathy [ Time Frame: Single time point. Blood sample will be obtained from patient participant immediately after nerve conduction studies are performed. ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
UK Robert Straus Behavioral Science LaboratoryLexingtonKentucky40508-
University of Kentucky - Kentucky Neuroscience InstituteLexingtonKentucky40536
Rani Priyanka Vasireddy, MBBS, MHA
[email protected]
859-218-5076
John T Slevin, M.D., M.B.A.
[email protected]
8593236702
John T Slevin, MD, Ph.D. (PRINCIPAL_INVESTIGATOR)
Zabeen K Mahuwala, MD (SUB_INVESTIGATOR)
Rani Priyanka Vasireddy, MBBS, MHA (SUB_INVESTIGATOR)

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By research site
UK Robert Straus Behavioral Science Laboratory· Lexington, KYUniversity of Kentucky - Kentucky Neuroscience Institute· Lexington, KY

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