Long-term, Substantial Weight Loss and Insulin Regulation of Lipolysis

Part of paid clinical trials in Rochester, Minnesota.

Sponsor
Mayo Clinic
Study ID
NCT03868592
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Not accepted

Interventions

  • Gastric sleeve/bariatric surgery — PROCEDURE
    weight loss

Study Details

It is not known how much improvement in insulin regulated lipolysis (the breakdown of triglycerides) occurs following substantial, sustained weight loss. Researchers will test the effects of inflammation and lipolysis regulation in people before and after bariatric surgery (sleeve gastrectomy) to answer these questions.

Key Dates

Start date
Aug 1, 2019
Status verified
Feb 2026
Primary completion
May 31, 2027
Completion
May 31, 2027

Study Design

Enrollment
30 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Gastric sleeve surgery
    before and after weight loss from bariatric surgery

Primary Outcome Measure

adipose macrophage content, adipose IL-6 and TNF gene expression [ Time Frame: Before bariatric surgery and approximately 1 year after surgery ]

Locations (1)

FacilityCityStateZIPSite coordinators
Mayo ClinicRochesterMinnesota559055
Reich Pamela
[email protected]
5072556062
Michael D Jensen, MD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Rochester, MN

By condition
Obesity / overweight
By specialty
EndocrinologyMetabolic healthWeight loss
By research site
Mayo Clinic· Rochester, MN

Related Studies