Mechanisms of Rumination Change in Adolescent Depression

Conditions

• Major Depressive Disorder
• Mood Disorders

Eligibility Criteria

Sex

ALL

Age

14 Years - 17 Years

Healthy Volunteers

Not accepted

Interventions

• Rumination-Focused CBT — BEHAVIORAL
  RF-CBT targets rumination and other maladaptive forms of emotion regulation such as suppression and avoidance and provides skills training in effectively coping with rumination. RF-CBT specifically targets rumination through psychoeducation, adopting a functional analytic approach to the learned habitual behavior of rumination, and a focus on shifting process style. The adolescent is taught to notice triggers to ruminate as well as the consequences of rumination and to shift into practicing a more adaptive strategy such as an attention training exercise, behavioral activation, thinking in a concrete way, or active problem-solving. RF-CBT directly teaches adolescents to recognize rumination or "when the participant gets stuck in their head" and to notice the influence this has on their mood.
• Relaxation-based Therapy — BEHAVIORAL
  Sessions will include progressive muscle relaxation, simple breathing techniques, and guided imagery that focus on bodily and somatic relaxation. Adolescents randomized to Relaxation Therapy (RelaxT) will also receive exercises to do as homework in between sessions, parallel to the RF-CBT group.

Study Details

This study will evaluate whether a newer treatment, rumination-focused cognitive behavioral treatment, which includes mindfulness and can be used to reduce ruminative habits, change ways in which key brain regions interact with each other (e.g.., often called connectivity), and whether these changes in habits and brain connectivity can reduce the risk for recurrence of depression in the next two years.

Key Dates

Start date

May 1, 2019

Status verified

Aug 2025

Primary completion

Apr 14, 2028

Completion

Mar 2, 2029

Study Design

Enrollment

183 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Arms

• Experimental: Rumination-Focused CBT
  RF-CBT is a manual-based treatment for prevention of depression, includes focus on ruminations, mental habits, concreteness training, and mindfulness.
• No Intervention: Treatment as Usual
  Participants are allowed to continue any therapy outside of the treatment study.
• Active Comparator: Relaxation-based therapy
  RelaxT includes an active comparison treatment that can be used to monitor and modify physiological responses to stress

Primary Outcome Measure

Rumination Responsiveness Scale (RRS) [ Time Frame: ~14-22 weeks ]

Central Contacts

• Scott A Langenecker, Ph.D.
  734-276-3889
  [email protected]
• Caty Escobar, M.S.
  301-648-3426
  [email protected]

Locations (3)

Find similar trials in Columbus, OH

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