Mechanisms of Pregnancy Vascular Adaptations

Part of paid clinical trials in Madison, Wisconsin.

Sponsor
University of Wisconsin, Madison
Study ID
NCT03806283
Status
Recruiting
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Conditions

  • Pre-Eclampsia
  • Vascular Diseases

Eligibility Criteria

Sex
FEMALE
Age
18 Years - 40 Years
Healthy Volunteers
Accepted

Interventions

  • Omental Biopsy — PROCEDURE
    The surgeon and clinical care team will conduct the c-section to deliver the baby and the placenta as clinically indicated. After delivery, during the closing procedures, the surgeon will indicate a time for a participating Ob/Gyn physician on the study team to collect the omental bio-specimen. Omentum is frequently excised or removed for clinical reasons during surgical procedures. Omentum has small blood vessels within it that have been used for evaluation of vascular functional changes in research. The investigators wish to isolate one to three vessels of 5 to 7 cm length. The surgeon will then close and the clinical care team will resume their standard of care activities.

Study Details

The investigators will collect omental tissue (research surgical excision) and placental tissue (standard of care clinical delivery) from both preeclamptic and non-preeclamptic women during their c-section and use these samples to study the blood vessels, specifically the expression/activation of the AT2R.

Key Dates

Start date
Nov 20, 2018
Status verified
Jan 2026
Primary completion
Apr 30, 2027
Completion
Apr 30, 2027

Study Design

Enrollment
166 participants (estimated)

Arms

  • Arm: Cohort 1 no Preeclampsia
    Cohort 1: mothers with no diagnosis of preeclampsia during pregnancy Omental Biopsy and placental collection will be performed
  • Arm: Cohort 2 mild or severe Preeclampsia
    Cohort 2: mothers with diagnosis of mild or severe preeclampsia during pregnancy Omental Biopsy and placental collection will be performed

Primary Outcome Measure

Quantify the vascular AT2R expression and vascular function in placental and omental vascular arteries in both preeclamptic and controlled pregnancies. [ Time Frame: 1 year ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
UnityPoint Health-Meriter HospitalMadisonWisconsin53715
Sathish Kumar, PhD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Madison, WI

By research site
UnityPoint Health-Meriter Hospital· Madison, WI

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