UAB Alzheimer's Disease Center Core Cohort - Imaging Substudy

Part of paid clinical trials in Birmingham, Alabama.

Sponsor
University of Alabama at Birmingham
Study ID
NCT03503331
Phase
PHASE2
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
50 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • [C-11]PiB-PET/MRI — DRUG
    All study participants will undergo brain imaging with \[C-11\]PiB-PET/MRI. \[C-11\]PiB is a PET imaging agent used primarily to measure the amount of abnormal protein (called beta-amyloid) in the brain. The investigator will also use this tracer to evaluate regional cerebral blood flow.

Study Details

The primary objective of this study is to measure the concentration and the regional brain distribution of pathologic amyloid deposition using the PET tracer \[C-11\]PiB in participants in the UAB Alzheimer's Disease Center cohort. Assessment of interactions between race and vascular risk factors, brain amyloid levels measured with \[C-11\]PiB-PET, and cognitive status will be the primary outcome of this imaging study.

Key Dates

Start date
Apr 20, 2018
Status verified
Dec 2025
Primary completion
Oct 31, 2028
Completion
Oct 31, 2028

Study Design

Enrollment
160 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC

Arms

  • Experimental: [C-11]PiB-PET/MRI
    All participants in this study will undergo an amyloid-PET imaging using the tracer \[C-11\]PiB with a simultaneous PET/MRI system. The \[C-11\]PiB dosage is 300-670 MBq (8 - 18 mCi) given intravenously, and the PET/MRI imaging time is approximately 60 min.

Primary Outcome Measure

Measurement of pathological beta-amyloid in the brain [ Time Frame: 5 years ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Alabama at Birmingham Medical CenterBirminghamAlabama35294
Jonathan McConathy, MD
[email protected]
205-996-7115
Jonathan McConathy, MD, PhD (PRINCIPAL_INVESTIGATOR)
Geldmacher David, MD (SUB_INVESTIGATOR)
Lapi Suzanne, PhD (SUB_INVESTIGATOR)
Jeffers Charlotte Denise, RPh (SUB_INVESTIGATOR)
Natelson Marissa, MD (SUB_INVESTIGATOR)
Roberson Erik, MD, PhD (SUB_INVESTIGATOR)

Find similar trials in Birmingham, AL

By condition
Alzheimer's disease
By specialty
NeurologyDementia careBrain disordersGeriatrics
By research site
University of Alabama at Birmingham Medical Center· Birmingham, AL

Related Studies