Characterization and Treatment of Adolescent Depression

Part of paid clinical trials in Bethesda, Maryland.

Sponsor
National Institute of Mental Health (NIMH)
Study ID
NCT03388606
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
11 Years - 25 Years
Healthy Volunteers
Accepted

Interventions

  • Growth Mindset — BEHAVIORAL
    30 Minute interactive video

Study Details

This research study seeks to find causes and treatments of depression in teenagers. The study goals are to increase our knowledge of treatments for depression and understand how the brain changes when teenagers have depression. The study will also compare teenagers with depression to those without mental health diagnoses. This outpatient study is recruiting participants ages 11-17 who are depressed. They must have a pediatrician or other medical provider, be medically healthy, and able to perform research tasks. They may not currently be hospitalized, psychotic or actively suicidal. Teenagers with depression are eligible even if they are taking medication. The study begins with an evaluation that includes clinical assessment, interviews, and questionnaires. * Visits may include paper-and-pencil and computer tests of mood, memory, and thinking; specialized computer games; and structural and brain imaging. If eligible, study participants may return several times a year for up to two years. This part of the study does not involve treatment. * Participants may be eligible for outpatient treatment for up to 25 weeks. This includes evidenced-based "talk" therapy. Participants may choose either Interpersonal Psychotherapy for Adolescents (IPT-A) or Cognitive Behavioral Therapy (CBT). If indicated, participants may opt to receive standard medication treatments along with psychotherapy. Research includes computer tasks and brain imaging. All clinical evaluations, research tasks and visits are free of cost. Participants are compensated for research activities. Parents and teenager must agree to the teenager s participation in research. The study is conducted at the NIH in Bethesda, Maryland and enrolls participants from the Washington DC Metro region within 50 miles of NIH. Transportation expenses are reimbursed by NIMH.

Key Dates

Start date
Dec 28, 2017
Status verified
Apr 2026
Primary completion
Jul 1, 2026
Completion
Jul 1, 2026

Study Design

Enrollment
4,100 participants (estimated)

Arms

  • Arm: Adolescents with major depression
    Adolescents with a current or past history of meeting full critieria for major depressive disorder
  • Arm: Healthy volunteer adolescents/young adults
    Adolescents with no history of significant psychiatric or medical disorders (as defined in the protocol) currently or in the past.
  • Arm: Parents of adolescent participants
    biological parent or legal guardian of an enrolled adolescent (who is a healthy volunteer, has s MDD \[subthreshold depression\], or has MDD \[Major Depressive Disorder\]) participant

Primary Outcome Measure

Mood and Feelings Questionnaire [ Time Frame: ongoing ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
National Institutes of Health Clinical CenterBethesdaMaryland20892
For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)
[email protected]
800-411-1222

Find similar trials in Bethesda, MD

By condition
Depression
By specialty
PsychiatryMental healthBehavioral health
By research site
National Institutes of Health Clinical Center· Bethesda, MD

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