Taste Bud-Derived Stem Cells in Humans

Part of paid clinical trials in Baltimore, Maryland.

Sponsor
National Institute on Aging (NIA)
Study ID
NCT03366168
Status
Recruiting
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Conditions

  • Diabetes

Eligibility Criteria

Sex
ALL
Age
18 Years - 120 Years
Healthy Volunteers
Accepted

Study Details

Background: Stem cells are found in body tissues. They can regenerate into more of the same cells or become other types of cell. Researchers want to use stem cells from taste buds to try to make cells that secrete insulin. Taste buds are found mostly on the tip and sides of the tongue. Researchers also want to study if the number of taste buds and stem cells decrease as people age. They will remove small pieces of tongue tissue (about the size of a pen tip). The taste buds will grow back. It is hoped that studying taste bud stem cells can lead to new diabetes treatments. Objectives: To see if stem cells from taste buds can be isolated in humans. Eligibility: Healthy adults at least 18 years old Design: Participants will be screened with: * Medical history * Physical exam * Blood and urine tests * Tongue photograph and mouth inspection. Food coloring will be applied to the tongue. Participants will have 1 study visit. They will not eat or drink anything 8 hours before. * They will give blood and urine samples. * They will have a tongue biopsy. Vital signs will be checked. The inside of the mouth will be examined. The tongue may be cleaned. The tongue will be numbed. Five small pieces of tissue will be taken with a small scissor. Any bleeding will be blotted with cotton and should stop in minutes. * Participants will be monitored for about 30 minutes. They will get a snack or meal. * They will be told how to take care of the tongue for the rest of the day. Participants will be called a week later to see how the

Key Dates

Start date
Dec 18, 2017
Status verified
Dec 2025
Primary completion
Dec 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
250 participants (estimated)

Arms

  • Arm: Group 1
    Ages 18-39 years
  • Arm: Group 2
    Ages 40-59 years
  • Arm: Group 3
    Ages 60 years old or older

Primary Outcome Measure

To demonstrate that in humans, epithelial stem cells isolated from the base of human taste buds can be propagated. [ Time Frame: Pilot Study ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
National Institute of Aging, Clinical Research UnitBaltimoreMaryland21224
NIA Studies Recruitment
[email protected]
410-350-3941

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