Novel Tracer Methods to Evaluate Muscle Protein Metabolism in Cirrhosis

Part of paid clinical trials in Cleveland, Ohio.

Sponsor
The Cleveland Clinic
Study ID
NCT03225677
Status
Recruiting
Apply to this trial

Conditions

  • Cirrhosis

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • blood draw and muscle biopsy — PROCEDURE
    One venous catheter will be used for bolus injection of multiple labeled AA at the beginning .The second venous catheter will inserted in the other arm for 5 ml of arterialized venous blood draw.Following the infusions, a single muscle biopsy will be performed from the vastus lateralis of the thigh using the Bergstromm needle.

Study Details

To determine the rate and mechanisms of skeletal muscle protein synthesis and breakdown in cirrhotic patients by using multiple tracers and single muscle biopsies.

Key Dates

Start date
Aug 3, 2017
Status verified
Nov 2025
Primary completion
Sep 30, 2027
Completion
Sep 30, 2027

Study Design

Enrollment
20 participants (estimated)

Arms

  • Arm: Patients with Cirrhosis
    Patients with a diagnosis of cirrhosis will have a blood draw and muscle biopsy will be performed.
  • Arm: controls
    control group should have serum ALT and AST within normal range and a blood draw and muscle biopsy will be performed

Primary Outcome Measure

Fractional Synthesis Rate [ Time Frame: 4 hours ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Cleveland Clinic FoundationClevelandOhio44195
Annette Bellar, MSLA
[email protected]
216-445-0688

Find similar trials in Cleveland, OH

By research site
Cleveland Clinic Foundation· Cleveland, OH

Related Studies