Collection of Immunology Specimens From Patients With Cancer or Blood Disorders, and Healthy Volunteers

Part of paid clinical trials in Los Angeles, California.

Sponsor
University of Southern California
Study ID
NCT03207854
Status
Recruiting
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Conditions

  • Healthy Subject
  • Hematologic and Lymphocytic Disorder
  • Hematopoietic and Lymphoid Cell Neoplasm
  • Immune System Disorder
  • Malignant Neoplasm

Eligibility Criteria

Sex
ALL
Age
19 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Biospecimen Collection — PROCEDURE
    Undergo collection of peripheral blood, bone marrow, and tissue
  • Laboratory Biomarker Analysis — OTHER
    Correlative studies
  • Questionnaire Administration — OTHER
    Ancillary studies

Study Details

This research trial collects and stores blood, tissue, and bone marrow specimens from patients with cancer or blood disorders, and healthy volunteers to study the immune system in a variety of different types of experiments, as well as associated clinical data as appropriate, focused on understanding mechanisms of immunotherapy.

Key Dates

Start date
Apr 12, 2017
Status verified
Mar 2026
Primary completion
Dec 31, 2026
Completion
Dec 31, 2027

Study Design

Enrollment
625 participants (estimated)

Arms

  • Arm: Ancillary-correlative (biospecimen collection)
    Patients and healthy normal volunteers undergo collection of peripheral blood samples for analysis via flow cytometry, RNASeq, immunohistochemistry, CyTOF experiments, cell cultures, and functional studies of immune cell subsets obtained by FACS. Patients also undergo collection of bone marrow and leukopheresis/leukoreduction specimens, and single cell suspensions and bulk excised tumor biopsies are obtained from routine testing for analysis via immunohistochemistry or CyTOF.

Primary Outcome Measure

Sample collection for immunology studies from patients with cancer or blood disorders, and healthy volunteers [ Time Frame: Baseline to 5 years ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
USC / Norris Comprehensive Cancer CenterLos AngelesCalifornia90033
Arta Zenunovic
[email protected]
323-442-5771
Casey O'Connell, MS (PRINCIPAL_INVESTIGATOR)

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By research site
USC / Norris Comprehensive Cancer Center· Los Angeles, CA

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