Natural History, Pathogenesis, and Outcome of Ocular Disorders

Conditions

• Eye Disease

Eligibility Criteria

Sex

ALL

Age

1 Month - 100 Years

Healthy Volunteers

Not accepted

Study Details

Background: The National Eye Institute (NEI) wants to evaluate and provide standard treatment to people with eye diseases. Objective: To examine and treat people with eye diseases and learn more about eye diseases and how they are inherited. Eligibility: People with eye diseases who can give consent or have a guardian who can consent for them. Asymptomatic first-degree relatives willing to provide a blood sample may also be enrolled for the purpose of genetic testing. Design: Participants will be screened with an eye exam. Participants will have 1-12 visits per year depending on their eye disease for up to 5 years. Visits last about 4 hours and could include: Medical and family history Physical exam Eye exam and photography. Oculography: They put on contact lenses or goggles. They watch spots on a computer screen for 20-30 minutes. Electrooculography: Small metal disks are placed on the skin next to both eyes. They look left and right in the dark and light for about 30 minutes. Electroretinography: They sit in the dark with their eyes patched. A small metal disk is taped to the forehead. After 30 minutes, the patches are removed and contact lenses put in. They watch flashing lights. Fluorescein angiography: A needle guides a thin plastic tube into an arm vein. A dye is injected through the tube and travels up the blood vessels in the eyes. Pictures are taken of the eyes. Immunosuppressive treatment Eye cell sample: Samples are obtained from swabbing, pressing paper on, or taking a small biopsy sample from the surface of the eye. Blood tests Skin, tear, urine, saliva, stool, or hair sample Exam under anesthesia for some children At each visit participants could get medications, eye drops, eye injections, laser treatments, or surgery.

Key Dates

Start date

Aug 3, 2016

Status verified

May 2026

Primary completion

Jul 1, 2026

Completion

Jul 1, 2026

Study Design

Enrollment

1,000 participants (estimated)

Arms

• Arm: Participants
  subjects with diagnosed or undiagnosed ocular conditions and/or their first-degree relatives

Primary Outcome Measure

No formal outcomes will be measured; however, the clinical assessments of enrolled participants can be used to measure the response to standard treatment. [ Time Frame: ongoing ]

Central Contacts

• Awilda V Holland, R.N.
  (301) 435-1831
  [email protected]

Locations (1)

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