Frameless Stereotactic Radiosurgery for Intact Brain Metastases

Part of paid clinical trials in Chicago, Illinois.

Sponsor
University of Chicago
Study ID
NCT02747303
Phase
PHASE2
Status
Recruiting
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Conditions

  • Brain Metastases

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Stereotactic Radiosurgery — PROCEDURE
    The SRS dose will depend on the maximum diameter of the gross tumor volume (GTV)

Study Details

This is a randomized study to determine if not treating planning target volume (PTV) margins during radiation therapy worsens progression free survival rates in patients with brain metastases.

Key Dates

Start date
Sep 5, 2023
Status verified
Dec 2025
Primary completion
Aug 22, 2028
Completion
Aug 22, 2028

Study Design

Enrollment
166 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Active Comparator: Stereotactic Radiosurgery to 2 mm GTV to PTV margins
  • Experimental: Stereotactic Radiosurgery to 0 mm GTV to PTV margins

Primary Outcome Measure

Progression free survival (PFS) rates estimated by the Kaplan-Meier method at 6 months [ Time Frame: 6 months ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of ChicagoChicagoIllinois60637
Steven J. Chmura, M.D., Ph.D. (PRINCIPAL_INVESTIGATOR)

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By research site
University of Chicago· Chicago, IL

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