Immunoinflammatory Response in Post Cardiac Arrest Syndrome (PCAS)

Part of paid clinical trials in Portland, Maine.

Sponsor
MaineHealth
Study ID
NCT02664831
Status
Recruiting
Apply to this trial

Conditions

  • Cardiac Arrest
  • Hypoxic Ischemic Encephalopathy (HIE)
  • Inflammation
  • Obesity

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Study Details

This is a prospective, observational study to investigate molecular mechanisms mediating the systemic inflammatory process, and changes to metabolism, and their impact on brain injury, survival, and functional outcomes after cardiac arrest. Investigators have shown that cardiac arrest induces changes in the numbers and properties of circulating immune cells, shifting the balance towards a pro-inflammatory phenotype and there is increased interest in the inflammatory pathways and the signaling mechanisms through which they are modulated. Participants will undergo blood sampling during 7 days following cardiac arrest, and analyses performed. Patient characteristics, clinical circumstances, and outcomes will be recorded and their associations with these inflammatory pathways characterized.

Key Dates

Start date
Jan 31, 2016
Status verified
Jul 2025
Primary completion
Jan 31, 2027
Completion
Jan 31, 2028

Study Design

Enrollment
400 participants (estimated)

Primary Outcome Measure

Correlations between inflammatory markers and clinical outcomes [ Time Frame: 14 days ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Maine Medical CenterPortlandMaine04102
David B Seder, MD
[email protected]
207-662-2179
Sergey Ryzhov, MD, PhD
[email protected]
David J Gagnon, PharmD (SUB_INVESTIGATOR)
David B Seder, MD (PRINCIPAL_INVESTIGATOR)
Sergey Ryzhov, MD, PhD (PRINCIPAL_INVESTIGATOR)
Teresa May, DO (SUB_INVESTIGATOR)
Richard Riker, MD (SUB_INVESTIGATOR)
Angela M Leclerc, PA-C (SUB_INVESTIGATOR)
Brittany Lachance, DO (SUB_INVESTIGATOR)
Patrick T Mailloux, DO (SUB_INVESTIGATOR)
Matthew Lynes, PhD (SUB_INVESTIGATOR)

Find similar trials in Portland, ME

By condition
Obesity / overweight
By specialty
EndocrinologyMetabolic healthWeight loss
By research site
Maine Medical Center· Portland, ME

Related Studies