Immune Cell Response to Stimuli

Part of paid clinical trials in Research Triangle Park, North Carolina.

Sponsor
National Institute of Environmental Health Sciences (NIEHS)
Study ID
NCT00397280
Status
Recruiting
Apply to this trial

Conditions

  • Inflammation

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Accepted

Study Details

This study will investigate the response of immune cells (neutrophils, monocytes) to various signals in the test tube to determine how they sense the signals in the body and what substances they produce in response to them. It will determine how the cells may, under certain circumstances, contribute to inflammation, and will measure substances in the blood plasma (the liquid, non-cellular part of the blood) that might stimulate white blood cells, in order to understand how the blood responds to possible disease-related conditions. Healthy normal volunteers 18 years of age and older who weigh at least 110 pounds may be eligible for this study. Participants give about 320 milliliters (mL) of blood (about 1 1/3 cups) or less at each donation. They donate no more than once every 8 weeks and no more than six times a year. On some occasions, less than 320 mL of blood may be drawn. The collected blood is separated into its components and specific cells are exposed to substances to examine their response....

Key Dates

Start date
Jul 13, 2009
Status verified
Feb 2026

Study Design

Enrollment
750 participants (estimated)

Arms

  • Arm: 1
    Any healthy donors meeting inclusion/exclusion criteria

Primary Outcome Measure

The objective is to define the signaling pathways activated by lipopolysaccharide (LPS) and other selected innate immunity stimuli, and the downstream inflammatory functional consequences, in human leukocytes in vitro. [ Time Frame: analysis of the study ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
NIEHS Clinical Research Unit (CRU)Research Triangle ParkNorth Carolina27709
NIEHS Join A Study Recruitment Group
[email protected]
855-696-4347

Find similar trials in Research Triangle Park, NC

By research site
NIEHS Clinical Research Unit (CRU)· Research Triangle Park, NC

Related Studies