Tumor Related Epilepsy

Part of paid clinical trials in Bethesda, Maryland.

Sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
Study ID
NCT02639325
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
8 Years - 99 Years
Healthy Volunteers
Not accepted

Study Details

Background: Some people with brain tumors have seizures related to the tumor. This is called tumor-related epilepsy. Usually brain tumors are treated by removing as much of the brain tumor as possible without causing problems. Researchers think this may improve the outcome for people with brain tumors. It may completely relieve or greatly reduce the number of seizures they have. Objectives: To evaluate people with brain tumors that are associated with seizures and to offer surgical treatment. Also, to study how surgery affects seizures. Eligibility: People age 8 and older who have a brain tumor with associated seizures. They must be willing to have brain surgery to treat their epilepsy. Design: Participants will be screened with a review of their medical records. Participants will have a medical history and physical exam. Participants will be admitted to the hospital at NIH. They will have Medical history Physical exam Neurological exam Tests of memory, attention, and thinking Questions about their symptoms and quality of life Blood drawn They may also have: MRI or CT scan. They will lie on a table that slides in and out of a machine that takes pictures. For part of the MRI, they will get a dye through an intravenous (IV) catheter. Video electroencephalography monitoring. Electrodes will be placed on the scalp. The participant s brain waves will be recorded while doing normal activities. Participants will be videotaped. Participants will keep a seizure diary before and after surgery. Participants will have surgery to remove their brain tumor and the brain area where their seizures start. They will stay in the hospital up to a week after surgery. Participants have for follow-up visits at NIH. ...

Key Dates

Start date
Jan 26, 2016
Status verified
Jan 2026
Primary completion
Jul 1, 2032
Completion
Jul 1, 2032

Study Design

Enrollment
100 participants (estimated)

Arms

  • Arm: Patients
    Patients who have solitary primary or recurrent brain tumor with associated seizures.

Primary Outcome Measure

change in seizure frequency, as measured by the Engel scale [ Time Frame: 3-6 months after surgery ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
National Institutes of Health Clinical CenterBethesdaMaryland20892
For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)
[email protected]
800-411-1222

Find similar trials in Bethesda, MD

By condition
Brain cancerEpilepsy
By specialty
OncologyNeuro-oncologyNeurologyBrain disorders
By research site
National Institutes of Health Clinical Center· Bethesda, MD

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