Whole Exome Sequencing in Finding Causative Variants in Germline DNA Samples From Patients With Peripheral Neuropathy Receiving Paclitaxel for Breast Cancer

Part of paid clinical trials in Boston, Massachusetts.

Sponsor
National Cancer Institute (NCI)
Study ID
NCT02610439
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
N/A - N/A
Healthy Volunteers
Not accepted

Interventions

  • Laboratory Biomarker Analysis — OTHER
    Correlative studies

Study Details

This research trial studies whole exome sequencing in finding causative variants in germline deoxyribonucleic acid (DNA) samples from patients with peripheral neuropathy receiving chemotherapy for breast cancer. Studying samples of germline DNA in the laboratory from patients with peripheral neuropathy receiving paclitaxel for breast cancer may help doctors learn more about changes that occur in DNA and identify biomarkers related to peripheral neuropathy.

Key Dates

Start date
Mar 25, 2014
Status verified
Mar 2026
Primary completion
Jan 1, 2100
Completion
Jan 1, 2100

Study Design

Enrollment
575 participants (estimated)

Arms

  • Arm: Ancillary-Correlative (whole exome sequencing)
    Previously collected germline DNA samples are analyzed via whole exome sequencing.

Primary Outcome Measure

Identification of rare coding variants of large effect that predict the risk of peripheral neuropathy [ Time Frame: Baseline ]

Locations (1)

FacilityCityStateZIPSite coordinators
Eastern Cooperative Oncology GroupBostonMassachusetts02215
Bryan P. Schneider
[email protected]
317-274-6473
Bryan P. Schneider (PRINCIPAL_INVESTIGATOR)

Find similar trials in Boston, MA

By condition
Breast cancer
By specialty
OncologyBreast oncologyWomen's health
By research site
Eastern Cooperative Oncology Group· Boston, MA

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