A Study of LY3023414 and Necitumumab in Squamous Lung Cancer

Part of paid clinical trials in Mobile, Alabama.

Sponsor
Eli Lilly and Company
Study ID
NCT02443337
Phase
PHASE2
Status
Terminated

Conditions

  • Non-small Cell Lung Cancer Metastatic

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • LY3023414 — DRUG
    Administered orally
  • Necitumumab — DRUG
    Administered IV

Study Details

The main purpose of this study is to evaluate the safety and activity of the study drug known as LY3023414 in combination with necitumumab in participants with metastatic squamous non-small cell lung cancer (NSCLC).

Key Dates

Start date
Jul 31, 2015
Status verified
Jan 2018
Primary completion
Sep 30, 2017
Completion
Sep 30, 2017

Study Design

Enrollment
31 participants (actual)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: LY3023414 + Necitumumab
    200 milligrams (mg) LY3023414 administered orally twice daily and 800 mg necitumumab administered intravenously (IV) on day 1 and day 8 of each cycle (21 day cycles). Participants may continue to receive treatment until discontinuation criteria are met.

Primary Outcome Measure

Percentage of Participants With a Complete Response (CR), Partial Response (PR) or Stable Disease (SD) at 6 Months: Disease Control Rate (DCR) [ Time Frame: 6 Months ]

Locations (14)

FacilityCityStateZIPSite coordinators
Southern Cancer Center, P.C.MobileAlabama36608-
Ironwood Cancer & Research CentersChandlerArizona85224-
Comprehensive Cancer Care and Research Institute of ColoradoEnglewoodColorado80113-
Florida Cancer SpecialistsFort MyersFlorida33916-
Florida Hospital Cancer InstituteOrlandoFlorida32804-
Florida Cancer SpecialistsSt. PetersburgFlorida33705-
Palm Beach Cancer InstituteWest Palm BeachFlorida33401-
Research Medical CenterKansas CityMissouri64132-
Oncology Hematology Care Inc.CincinnatiOhio45242-
Chattanooga Oncology HematologyChattanoogaTennessee37404-
SMO Sarah Cannon Research Inst.NashvilleTennessee37203-
Tennessee OncologyNashvilleTennessee37203-
Center for Cancer and Blood DisordersFort WorthTexas76104-
University of Virginia HealthCharlottesvilleVirginia22908-

Find similar trials in Mobile, AL

By research site
Southern Cancer Center, P.C.· Mobile, ALIronwood Cancer & Research Centers· Chandler, AZComprehensive Cancer Care and Research Institute of Colorado· Englewood, COFlorida Cancer Specialists· Fort Myers, FLFlorida Hospital Cancer Institute· Orlando, FLFlorida Cancer Specialists· St. Petersburg, FL

Related Studies