Comparative Autoantibody and Immunologic Cell Marker Study

Part of paid clinical trials in Atlanta, Georgia.

Sponsor
Emory University
Study ID
NCT02422875
Status
Enrolling By Invitation

Conditions

  • Autoimmune Diseases
  • Communicable Diseases
  • Lupus Erythematosus, Systemic

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Study Details

The purpose of this study is to compare immune phenotype, function, and specificity of B lymphocytes from different developmental stages in autoimmune patients to B cells from infectious disease patients and healthy controls.

Key Dates

Start date
Aug 31, 2012
Status verified
Sep 2025
Primary completion
May 31, 2028
Completion
May 31, 2028

Study Design

Enrollment
2,500 participants (estimated)

Arms

  • Arm: Healthy Controls
    Subjects are healthy persons without any autoimmune conditions or infectious diseases
  • Arm: Autoimmune Disease
    Subjects diagnosed with autoimmune disease including but not limited to: Systemic Lupus Erythematosus (SLE), Sjögren's Syndrome (SS), Scleroderma, Myositis, Juvenile Idiopathic Arthritis (JIA), Rheumatoid Arthritis (RA), inflammatory arthritis, undifferentiated connective tissue disease, idiopathic thrombocytopenic purpura (ITP), Graft vs Host Disease (GVHD), Autoimmune Lymphoproliferative Syndrome (ALPS) and IgG4-related disease
  • Arm: Infectious Disease
    Subjects diagnosed with an infectious disease including but not limited to: Hepatitis C, Epstein Barr Virus (infectious mononucleosis - EBV), Sepsis, Guillain-Barre syndrome (GBS), Mycoplasma pneumoniae or Human Immunodeficiency Virus (HIV)
  • Arm: Autoimmune - Family
    Subjects have a brother, sister, mother, father, or child with an autoimmune disease
  • Arm: Vaccination
    Subjects have received or will receive a vaccination as part of regular standard of care from their healthcare provider or other outside source

Primary Outcome Measure

Distribution of autoreactive B cells within bone marrow [ Time Frame: Baseline ]

Locations (3)

FacilityCityStateZIPSite coordinators
Emory University HospitalAtlantaGeorgia30322-
Emory University Winship Cancer InstituteAtlantaGeorgia30322-
Grady Health SystemAtlantaGeorgia30322-

Find similar trials in Atlanta, GA

By research site
Emory University Hospital· Atlanta, GAEmory University Winship Cancer Institute· Atlanta, GAGrady Health System· Atlanta, GA

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