A 24 Month Phase 2a Open Label, Randomized Study of Avastin®, Lucentis®, or Eylea® (Anti-VEGF Therapy) Administered in Combination With Fovista® (Anti-PDGF BB Pegylated Aptamer)
Part of paid clinical trials in Phoenix, Arizona.
- Sponsor
- Ophthotech Corporation
- Study ID
- NCT02387957
- Phase
- PHASE2
- Status
- Terminated
Conditions
Eligibility Criteria
- Sex
- ALL
- Age
- 50 Years - N/A
- Healthy Volunteers
- Not accepted
Interventions
- Fovista® — DRUG
- bevacizumab — DRUG
- ranibizumab — DRUG
- aflibercept — DRUG
Study Details
To evaluate the safety of intravitreal (IVT) Fovista® administered in combination with anti-VEGF therapy.
Key Dates
- Start date
- Apr 26, 2016
- Status verified
- Feb 2019
- Primary completion
- Jan 31, 2017
- Completion
- Jan 31, 2017
Study Design
- Enrollment
- 63 participants (actual)
- Allocation
- RANDOMIZED
- Intervention model
- PARALLEL
- Primary purpose
- TREATMENT
Arms
- Experimental: Fovista® plus bevacizumabFovista® 1.5 mg intravitreal injection + bevacizumab 1.25 mg intravitreal injection
- Experimental: Fovista® plus ranibizumabFovista® 1.5 mg intravitreal injection + 0.5 mg ranibizumab intravitreal injection
- Experimental: Fovista® plus afliberceptFovista® 1.5 mg intravitreal injection + 2.0 mg aflibercept intravitreal injection
Primary Outcome Measure
Total Numer of Systemic Adverse Events [ Time Frame: 2 years ]
Locations (24)
| Facility | City | State | ZIP | Site coordinators |
|---|---|---|---|---|
| - | Phoenix | Arizona | 85014 | - |
| - | Beverly Hills | California | 90211 | - |
| - | Sacramento | California | 95819 | - |
| - | Santa Ana | California | 92705 | - |
| - | New London | Connecticut | 06320 | - |
| - | Fort Lauderdale | Florida | 33308 | - |
| - | Fort Myers | Florida | 33912 | - |
| - | Augusta | Georgia | 30909 | - |
| - | Oak Forest | Illinois | 60452 | - |
| - | Boston | Massachusetts | 02114 | - |
| - | Worcester | Massachusetts | 01605 | - |
| - | Southfield | Michigan | 48034 | - |
| - | Minneapolis | Minnesota | 55435 | - |
| - | Reno | Nevada | 89502 | - |
| - | Rochester | New York | 14620 | - |
| - | Cleveland | Ohio | 44130 | - |
| - | Huntingdon Valley | Pennsylvania | 19006 | - |
| - | Ladson | South Carolina | 29456 | - |
| - | Abilene | Texas | 85014 | - |
| - | Amarillo | Texas | 79106 | - |
| - | San Antonio | Texas | 78240 | - |
| - | The Woodlands | Texas | 77384 | - |
| - | Silverdale | Washington | 98383 | - |
| - | Morgantown | West Virginia | 26506 | - |
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