Magnetic Resonance Elastography in Patients With Abdominal Aortic Aneurysms

Part of paid clinical trials in Columbus, Ohio.

Sponsor
Ohio State University
Study ID
NCT02387255
Status
Recruiting
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Conditions

  • Abdominal Aortic Aneurysm

Eligibility Criteria

Sex
ALL
Age
20 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Resoundant Driver System — DEVICE
    This device is used to generate vibrations at the area of interest. The device has an active driver, a loud speaker sitting outside the scanner area, and a passive driver, which is shaped like a silicone paddle, which is secured with velcro straps to the area being imaged. Sound waves from the active driver travel through a tube attached to the passive driver and generate vibrations, images of which are captured by the MR scanner.

Study Details

The main objective of this study is to utilize Magnetic Resonance Elastography (MRE) to determine tissue stiffness of abdominal aortic aneurysms (AAA). For patients with AAA, MRE is a more sensitive and superior method of determining the risk for rupture of AAA based on stiffness estimates when compared to the current, crude method of assessing risk based on measurement of the diameter of the aneurysm. The investigators will also validate the stiffness estimates against gold standard i.e. mechanical testing and histopathology only AAA patients undergoing AAA surgery.

Key Dates

Start date
Oct 31, 2014
Status verified
Apr 2025
Primary completion
Oct 31, 2028
Completion
Oct 31, 2028

Study Design

Enrollment
165 participants (estimated)

Arms

  • Arm: Normal Volunteers
    60 normal volunteers will be recruited. Each volunteer will undergo a single MRE scan (with Resoundant driver System ) of their abdominal aorta.
  • Arm: Patients with AAA
    Fifty to sixty five patients with AAA will be recruited. These patients will undergo MRE (with Resoundant driver system) of their AAA every six months for three years, or until the study ends or until the time of surgical repair or death due to rupture of AAA or other causes.
  • Arm: Open Surgical Repair Patients
    Fifty to sixty five patients patients undergoing open surgical repair will be recruited and undergo MRE (with Resoundant driver system) prior to surgery

Primary Outcome Measure

MRE-Derived Shear Stiffness in kPa [ Time Frame: Upto 36 months at every 6 months ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
The Ohio State University Medical CenterColumbusOhio43210
Kristin L Thompson, B.S.
[email protected]
614-366-5429
Arunark Kolipaka, PhD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Columbus, OH

By research site
The Ohio State University Medical Center· Columbus, OH

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