The Delayed Intervention and Surveillance for Small Renal Masses (DISSRM) Registry

Part of paid clinical trials in Baltimore, Maryland.

Sponsor
Abramson Cancer Center at Penn Medicine
Study ID
NCT02346435
Status
Recruiting
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Conditions

  • Kidney Neoplasm

Eligibility Criteria

Sex
ALL
Age
18 Years - 100 Years
Healthy Volunteers
Accepted

Study Details

Retrospective studies indicate that active surveillance for clinically localized, small renal masses (cT1a, \<=4cm) is safe. It is our hypothesis that active surveillance is safe and efficacious when compared prospectively to patients undergoing immediate intervention for their small renal mass.

Key Dates

Start date
Jan 31, 2009
Status verified
Sep 2025
Primary completion
Jan 31, 2028
Completion
Jan 31, 2028

Study Design

Enrollment
600 participants (estimated)

Arms

  • Arm: Active Surveillance
  • Arm: Immediate Intervention
    May include patients undergoing open or minimally-invasive partial nephrectomy, radical nephrectomy or energy ablation.
  • Arm: Crossover (Delayed Intervention)
    Initially patients in active surveillance that meet progression criteria or elect to undergo delayed intervention.

Primary Outcome Measure

Disease-specific survival [ Time Frame: 5 years ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Johns Hopkins HospitalBaltimoreMaryland21287
Phillip M Pierorazio, MD
[email protected]
4105025984
Phillip M Pierorazio, MD (SUB_INVESTIGATOR)
Mohamad E Allaf, MD, MBA (PRINCIPAL_INVESTIGATOR)

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By research site
Johns Hopkins Hospital· Baltimore, MD

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