Genetic and Epigenetic Signatures of Translational Aging Laboratory Testing (GESTALT)

Part of paid clinical trials in Baltimore, Maryland.

Sponsor
National Institute on Aging (NIA)
Study ID
NCT02339012
Status
Recruiting
Apply to this trial

Conditions

  • Frail
  • Healthy Volunteers
  • Non-Healthy/Non-Frail

Eligibility Criteria

Sex
ALL
Age
20 Years - 120 Years
Healthy Volunteers
Accepted

Study Details

Background: \- Biomarkers are substances in people s blood and tissues. They help researchers understand diseases and signs of aging. Scientists want to do more research on biomarkers to find ways to improve quality of life in old age. Objective: \- To learn more about biomarkers and their relationship to aging. Eligibility: \- Adults at least 20 years old who weigh at least 110 pounds and have a body mass index below 30. They must agree that their genetic samples can be collected, studied, and stored. Design: * Participants will be screened with medical history, physical exam, EKG and blood and urine tests. * Participants will have 3-day visits. They will return every 2 years. * All visits include: * Blood and urine collection * Physical performance tests * Health questionnaires * Memory and problem-solving tests * Magnetic Resonance Imaging (MRI) and Computerized Tomography (CT) scans. * Muscle metabolism/ exercise tests * Taste strips * Muscle and/or skin biopsies/ red light therapy * Retinal imaging/ eye tracking * Sleep study * ODD visits also include: * Cytapheresis * Bone marrow aspirate * EVEN visits also include: * Hyperglycemic CLAMP * Lumbar Puncture (LP) * Continuous Glucose Monitor (CGM)

Key Dates

Start date
Mar 15, 2015
Status verified
May 2026
Primary completion
Dec 31, 2099
Completion
Dec 31, 2099

Study Design

Enrollment
900 participants (estimated)

Arms

  • Arm: Frail
    frail individuals ages 50-64 years; 65-79 years; 80+ years
  • Arm: Healthy
    healthy individuals ages 20-34 years; 35-39 years; 50-64 years; 65-79 years; 80+ years
  • Arm: Non-Healthy/Non-Frail
    non-healthy/non-frail individuals ages 20-34 years; 35-39 years; 50-64 years; 65-79 years; 80+ years

Primary Outcome Measure

Development of state-of-theart expression/methylation /protein PBMC atlas in aging [ Time Frame: Ongoing ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
National Institute of Aging, Clinical Research UnitBaltimoreMaryland21224
NIA Studies Recruitment
[email protected]
410-350-3941

Find similar trials in Baltimore, MD

By research site
National Institute of Aging, Clinical Research Unit· Baltimore, MD

Related Studies