Using Microbial Genomics to Elucidate the Source of Central-line Associated Bloodstream Infections

Conditions

• Central Line-associated Bloodstream Infections
• Laboratory-confirmed Bloodstream Infection
• Mucosal Barrier Injury

Eligibility Criteria

Sex

ALL

Age

N/A - N/A

Healthy Volunteers

Not accepted

Study Details

Central line-associated bloodstream infections (CLABSIs) are the most common healthcare-associated infection in children and are associated with morbidity and mortality. This study will attempt to identify the source of bloodstream infections (BSIs) in children with CLABSI because we hypothesize that many of the BSIs that are currently classified as CLABSIs are actually laboratory-confirmed bloodstream infections (LCBI) that may be a result of mucosal barrier injury (MBI), also known as MBI-LCBI. In order to study this, we will isolate bacteria from multiple body sites of children that have BSI in order to compare these bacteria to the strain growing in their blood using whole-genome DNA sequencing. We will also evaluate biomarkers of MBI of the respiratory tract and GI tract.

Key Dates

Start date

Nov 30, 2014

Status verified

May 2026

Primary completion

Dec 31, 2027

Completion

Dec 31, 2027

Study Design

Enrollment

60 participants (estimated)

Arms

• Arm: Subject with suspected MBI
• Arm: Subjects without suspected MBI

Primary Outcome Measure

Phylogenetic relationships (on SNP scale) of bacteria isolated from different body sites [ Time Frame: Up to 2 years ]

Central Contacts

• Rachel Bernier, MPH
  857-218-5348
  [email protected]

Locations (1)

Find similar trials in Boston, MA