A Phase 1 Study of MEDI4736 in Combination With Tremelimumab in Subjects With Advanced Solid Tumors

Part of paid clinical trials in Scottsdale, Arizona.

Sponsor
MedImmune LLC
Study ID
NCT02261220
Phase
PHASE1
Status
Completed

Conditions

  • Advanced Solid Tumors

Eligibility Criteria

Sex
ALL
Age
18 Years - 99 Years
Healthy Volunteers
Not accepted

Interventions

  • MEDI4736 — BIOLOGICAL
    MEDI4736 is administered by IV infusion in combination with tremelimumab
  • tremelimumab — BIOLOGICAL
    Tremelimumab is administered by IV infusion in combination with MEDI4736

Study Details

This is a multicenter, open-label, dose-exploration and dose-expansion study to evaluate the safety, tolerability, antitumor activity, PK and immunogenicity of MEDI4736 in combination with tremelimumab in subjects with select advanced solid tumors.

Key Dates

Start date
Oct 13, 2014
Status verified
Mar 2020
Primary completion
Jan 27, 2020
Completion
Jan 27, 2020

Study Design

Enrollment
380 participants (actual)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: MEDI4736 + Tremelimumab
    Subjects with multiple tumor types.

Primary Outcome Measure

Number of subjects reporting adverse events [ Time Frame: Screening through 15 months after the last subject enters re-treatment ]

Locations (30)

FacilityCityStateZIPSite coordinators
Research SiteScottsdaleArizona85258-
Research SiteDuarteCalifornia91010-
Research SiteLa JollaCalifornia92093-
Research SiteLos AngelesCalifornia90025-
Research SiteLos AngelesCalifornia90095-
Research SiteWhittierCalifornia90603-
Research SiteAuroraColorado80045-
Research SiteNew HavenConnecticut06510-
Research SiteMiami BeachFlorida33140-
Research SiteTampaFlorida33612-
Research SiteChicagoIllinois60611-
Research SiteChicagoIllinois60637-
Research SiteIowa CityIowa52242-1008-
Research SiteLouisvilleKentucky40202-
Research SiteAnn ArborMichigan48109-
Research SiteNew YorkNew York10065-
Research SiteNew YorkNew York10116-
Research SiteThe BronxNew York10461-
Research SiteCincinnatiOhio45219-
Research SiteClevelandOhio44106-
Research SitePortlandOregon97213-
Research SitePortlandOregon97239-
Research SitePhiladelphiaPennsylvania19111-
Research SitePittsburghPennsylvania15212-
Research SiteGreenvilleSouth Carolina29605-
Research SiteDallasTexas75230-
Research SiteHoustonTexas77521-
Research SiteSan AntonioTexas78229-
Research SiteFairfaxVirginia22031-
Research SiteSeattleWashington98104-

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By research site
Research Site· Scottsdale, AZResearch Site· Duarte, CAResearch Site· La Jolla, CAResearch Site· Los Angeles, CAResearch Site· Whittier, CAResearch Site· Aurora, CO

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