Studies of the Natural History, Pathogenesis, and Outcome of Idiopathic Systemic Vasculitis

Part of paid clinical trials in Bethesda, Maryland.

Sponsor
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Study ID
NCT02257866
Status
Recruiting
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Conditions

  • ANCA-Associated Vasculitis
  • Giant Cell Arteritis
  • Polyarteritis Nodosa
  • Relapsing Polychondritis
  • Takayasu's Arteritis

Eligibility Criteria

Sex
ALL
Age
3 Years - N/A
Healthy Volunteers
Accepted

Study Details

Background: \- Vasculitis is a group of diseases that inflame and damage blood vessels and tissue. It can cause many medical problems. Few tests can diagnose the disease, and none can reliably predict a relapse. Researchers want to study people s genes and follow people over time to see how the disease affects them. Objective: \- To learn the signs, symptoms, imaging tests, genetic markers, and blood tests that can help identify people with vasculitis and predict what will happen to them over time. Eligibility: * People age 3 and older who have or are thought to have vasculitis, or are related to someone with it. * Healthy volunteers. Design: * Participants will be evaluated by a doctor who has expertise caring for patients with vasculitis. * Participants will give a blood sample. Some will give a urine sample. * Some participants may have brushings or biopsies taken from the inside lining of the nose. * Images of participants blood vessels may be taken using scans. For some scans, participants will lie on a table that moves in and out of a cylinder that takes pictures. For some scans, a contrast agent may be injected into an arm vein. Other scans may use a radioactive form of sugar. Healthy minors will not have scans. * Some participants will answer questionnaires. - Some participants will have their tests done at NIH. Others will have their doctor take the blood, saliva, or cheek swab samples and send them to NIH. * Some participants will have one visit lasting 1-2 (but sometimes up to 4) days. Some participants may have follow-up visits every 3 - 6 months, indefinitely.

Key Dates

Start date
Sep 29, 2014
Status verified
Feb 2026
Primary completion
Jan 1, 2050
Completion
Jan 1, 2050

Study Design

Enrollment
4,000 participants (estimated)

Arms

  • Arm: Healthy Volunteers
    Patients without known auto immune diseases
  • Arm: Vasculitis
    Patients with known or suspected vasculitis age 5 or older

Primary Outcome Measure

To study the pathogenesis of patients affected with idiopathic systemic vasculitis, including clinical, radiographic, immunological, and genetic characteristics of the disease [ Time Frame: end of study ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
National Institutes of Health Clinical CenterBethesdaMaryland20892
For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)
[email protected]
800-411-1222

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By research site
National Institutes of Health Clinical Center· Bethesda, MD

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