Ublituximab + Ibrutinib in Select B-cell Malignancies

Part of paid clinical trials in Huntsville, Alabama.

Sponsor
TG Therapeutics, Inc.
Study ID
NCT02013128
Phase
PHASE1/PHASE2
Status
Completed

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Ublituximab — DRUG
    Ublituximab (IV infusion)
  • Ibrutinib — DRUG
    Ibrutinib oral daily dose

Study Details

The purpose of this study is to evaluate the safety and effectiveness of Ublituximab in combination with Ibrutinib in patients with advanced hematologic malignancies.

Key Dates

Start date
Jan 6, 2014
Status verified
Oct 2022
Primary completion
Dec 31, 2015
Completion
Dec 31, 2015

Study Design

Enrollment
66 participants (actual)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Ublituximab + ibrutinib
    Ublituximab: IV infusion dose Days 1, 8 and 15 followed by maintenance infusions Ibrutinib: Fixed oral daily dose

Primary Outcome Measure

To evaluate the safety of ublituximab in combination with ibrutinib in patients with select B-cell malignancies [ Time Frame: 28 days (1 cycle of therapy) ]

Locations (18)

FacilityCityStateZIPSite coordinators
TG Therapeutics Investigational Trial SiteHuntsvilleAlabama35805-
TG Therapeutics Investigational Trial SiteTucsonArizona85710-
TG Therapeutics Investigational Trial SiteSanta BarbaraCalifornia93105-
TG Therapeutics Investigational Trial SiteBoulderColorado80303-
TG Therapeutics Investigational Trial SiteNilesIllinois60714-
TG Therapeutics Investigational Trial SiteUrbanaIllinois61801-
TG Therapeutics Investigational Trial SiteBethesdaMaryland20817-
TG Therapeutics Investigational Trial SiteMorristownNew Jersey07962-
TG Therapeutics Investigational Trial SitePortlandOregon97213-
TG Therapeutics Investigational Trial SiteSpringfieldOregon97477-
TG Therapeutics Investigational Trial SiteGreenvilleSouth Carolina29615-
TG Therapeutics Investigational Trial SiteMemphisTennessee38120-
TG Therapeutics Investigational Trial SiteAustinTexas78705-
TG Therapeutics Investigational Trial SiteDallasTexas75230-
TG Therapeutics Investigational Trial SiteTylerTexas75702-
TG Therapeutics Investigational Trial SiteBlacksburgVirginia24060-
TG Therapeutics Investigational Trial SiteFairfaxVirginia22031-
TG Therapeutics Investigational Trial SiteVancouverWashington98684-

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