Cell Collection to Study Eye Diseases

Part of paid clinical trials in Bethesda, Maryland.

Sponsor
National Eye Institute (NEI)
Study ID
NCT01432847
Status
Recruiting
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Conditions

  • AMD
  • Retinal Degeneration
  • Retinal Disease
  • Retinitis Pigmentosa

Eligibility Criteria

Sex
ALL
Age
1 Day - 120 Years
Healthy Volunteers
Accepted

Study Details

Background: \- Best Vitelliform Dystrophy (Best disease), Late-Onset Retinal Degeneration (L-ORD), and Age-Related Macular Degeneration (AMD) all affect the retina, the light sensing area at the back of the eye. Doctors cannot safely obtain retinal cells to study these diseases. However, cells collected from hair follicles, skin, saliva, urine, and blood can be used for research. Researchers want to collect cells from people with Best disease, L-ORD, and AMD, and compare their cells with those of healthy volunteers. Objectives: \- To collect hair, skin, saliva, urine, and/or blood samples to study three eye diseases that affect the retina: Best disease, L-ORD, and AMD. Eligibility: * Individuals affected with ocular condition is one year of age or older. * Individuals affected with Best disease, L-ORD, or AMD is 18 years of age or older. * Unaffected individuals are seven years of age or older. Design: * The study requires one visit to the National Eye Institute. * Participants will be screened with a medical and eye disease history. They may also have an eye exam. * Participants will provide a hair sample, saliva sample, urine sample, blood sample, and/or a skin biopsy. The hair will be collected from the back of the head, and the skin will be collected from the inside of the upper arm.

Key Dates

Start date
Sep 7, 2011
Status verified
Jun 2026

Study Design

Enrollment
930 participants (estimated)

Arms

  • Arm: Affected
    Participants affected by ocular diseases/conditions.
  • Arm: Healthy Volunteers
    Age, sex, and ethnicity-matched to participants with ocular conditions or the unaffected relatives of participants with ocular conditions

Primary Outcome Measure

Discovery of therapeutic interventions for these ocular diseases [ Time Frame: Duration of protocol ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
National Institutes of Health Clinical CenterBethesdaMaryland20892
Nancy Chen, B.S.
[email protected]
240-551-7020

Find similar trials in Bethesda, MD

By condition
Age-related macular degeneration
By specialty
OphthalmologyRetina
By research site
National Institutes of Health Clinical Center· Bethesda, MD

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