VRC 900: Evaluation of Tissue-Specific Immune Responses in Adults 18 Years of Age and Older

Conditions

• Blood Specimen Collection
• Immune System Processes
• Immunity, Mucosal

Eligibility Criteria

Sex

ALL

Age

18 Years - 120 Years

Healthy Volunteers

Accepted

Study Details

Background: \- The Vaccine Research Center (VRC) is dedicated to understanding immune responses associated with prevention and treatment of infectious diseases. To study these immune responses, researchers need to collect specimens and images from individuals who have recently had a vaccination or recovered from an infection. These specimens and images are used to study different diseases and immune responses, and can be used to investigate ways to prevent or treat different medical conditions. Objectives: \- To evaluate blood and other tissue samples for immune responses to vaccines and natural infections. Eligibility: \- Healthy volunteers at least 18 years of age who agree to donate specimens for research purposes. Design: * Participants will have clinical evaluations and will be asked to provide some of the following samples, depending on the research question being addressed. All procedures and sample donations are optional and voluntary: * Blood samples through regular blood draws (for whole blood) and apheresis (to collect specific parts of the blood such as plasma or white blood cells) * Urine, semen, saliva, or vaginal swab samples * Tissue samples or biopsy specimens * Undergo procedures such as bronchoscopy (lung and respiratory tract), gastrointestinal endoscopy (stomach and upper intestinal tract), or colonoscopy (lower intestinal tract) to obtain tissue samples * Undergo imaging studies such as positron emission tomography (PET) or computed tomography (CT) scans Duration of participation is variable depending on the research question but will usually last up to 1 year. \- Participants will be compensated for participation.

Key Dates

Start date

May 18, 2010

Status verified

Jan 2026

Study Design

Enrollment

500 participants (estimated)

Arms

• Arm: 1
  Participants 18 years of age or older willing to donate blood and tissue specimens and participate in imaging studies to evaluate the components of the immune system

Primary Outcome Measure

To use specimens and accumulated data for enhancement of understanding the correlates of immune protection. [ Time Frame: Throughout the study ]

Central Contacts

• OPS Team, VRC
  Not Listed
  [email protected]

Locations (1)

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