Molecular Analysis of Samples From Patients With Diffuse Intrinsic Pontine Glioma and Brainstem Glioma

Part of paid clinical trials in Washington D.C., District of Columbia.

Sponsor
Children's National Research Institute
Study ID
NCT01106794
Status
Recruiting
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Conditions

  • Brainstem Glioma
  • Diffuse Intrinsic Pontine Glioma

Eligibility Criteria

Sex
ALL
Age
N/A - 21 Years
Healthy Volunteers
Not accepted

Study Details

The purpose of this study is to prospectively collect specimens from pediatric patients with diffuse intrinsic pontine glioma or brainstem glioma, either during therapy or at autopsy, in order to characterize the molecular abnormalities of this tumor.

Key Dates

Start date
Apr 30, 2010
Status verified
Aug 2024
Primary completion
Apr 30, 2025
Completion
Apr 30, 2030

Study Design

Enrollment
100 participants (estimated)

Arms

  • Arm: Patient samples
    Fresh-frozen and fixed tumor samples, correspondent normal brain tissue samples, cerebrospinal fluid, urine, and serum samples from patients affected with diffuse intrinsic pontine glioma or brainstem glioma

Primary Outcome Measure

Genome-wide expression patterns of RNA in tumor samples, normal brainstem tissue and cerebrospinal fluid using Affymetrix gene expression profiling [ Time Frame: 5 years ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Children's National Medical CenterWashington D.C.District of Columbia20010
Javad Nazarian, PhD (PRINCIPAL_INVESTIGATOR)
Roger Packer, MD (SUB_INVESTIGATOR)
Suresh Magge, MD (SUB_INVESTIGATOR)
Amanda L Muhs, MD (SUB_INVESTIGATOR)

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Children's National Medical Center· Washington D.C., DC

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