Collection of Human Samples to Study Hairy Cell and Other Leukemias, and to Develop Recombinant Immunotoxins for Cancer Treatment

Part of paid clinical trials in Bethesda, Maryland.

Sponsor
National Cancer Institute (NCI)
Study ID
NCT01087333
Status
Recruiting
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Conditions

  • Adult T Cell Lymphoma (ATL)
  • Chronic Lymphocytic Leukemia (CLL)
  • Cutaneous T Cell Lymphoma (CTCL)
  • Hairy Cell Leukemia (HCL)
  • Non-Hodgkins Lymphoma (NHL)

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Study Details

Background: \- Researchers who are studying hairy cell leukemia, and how the disease compares with other disorders, are interested in obtaining additional samples from leukemia patients and healthy volunteers. The investigators are particularly interested in samples from individuals who have diseases that can be treated with a new type of drug called immunotoxin, in which an antibody carrying a toxin binds to a cancer cell and allows the toxin to kill the cell. Objectives: \- To collect a variety of clinical samples, including blood, urine, lymph samples, and other tissues, in order to study the samples and develop new treatments for leukemia. Eligibility: \- Individuals 18 years of age and older who have been diagnosed with leukemia or other kinds of blood and lymphatic system cancers, or who are healthy volunteers. Design: * Individuals who have leukemia will be asked to provide blood, bone marrow, urine, and tumor tissue samples as requested by the researchers. Healthy volunteers will provide only blood and urine samples. * No treatment will be given as part of this protocol.

Key Dates

Start date
Mar 2, 2010
Status verified
Oct 2025

Study Design

Enrollment
1,263 participants (estimated)

Arms

  • Arm: 1
    Patients with hematologic malignancies or solid tumors.
  • Arm: 2
    Normal Donors who are defined as individuals without a diagnosis of or history of any cancer.

Primary Outcome Measure

Tissue Acquisition [ Time Frame: 4 weeks ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
National Institutes of Health Clinical CenterBethesdaMaryland20892-

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National Institutes of Health Clinical Center· Bethesda, MD

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