Proton Beam Radiotherapy for Medulloblastoma and Pineoblastoma

Part of paid clinical trials in Boston, Massachusetts.

Sponsor
Massachusetts General Hospital
Study ID
NCT01063114
Status
Completed

Conditions

Eligibility Criteria

Sex
ALL
Age
3 Years - 25 Years
Healthy Volunteers
Not accepted

Interventions

  • proton beam radiation — RADIATION
    Given once a day, 5 days a week (Monday-Friday)

Study Details

There are two types of external radiation treatments (proton beam and photon beam). As part of the participant's treatment, they will receive radiation to the entire central nervous system (CNS); this is known as craniospinal irradiation (CSI). In the past, photon radiation therapy has been used for CSI. In this study we will be examining the effects of proton beam radiation therapy. Studies have suggested that this kind of radiation can cause less damage to normal tissue than photon radiation therapy. The physical characteristics of proton beam radiation let the doctor safely deliver the amount of radiation delivered to the tumor that is normally delivered through standard therapy but spare more normal tissue in the process.

Key Dates

Start date
Apr 8, 2010
Status verified
Aug 2025
Primary completion
Nov 30, 2021
Completion
Nov 30, 2021

Study Design

Enrollment
90 participants (actual)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Proton Beam Radiation
    Proton Beam Radiation

Primary Outcome Measure

Cumulative Incidence of Ototoxicity [ Time Frame: 3- and 5- years post radiation treatment ]

Locations (2)

FacilityCityStateZIPSite coordinators
Massachusetts General HospitalBostonMassachusetts02115-
MD Anderson Cancer CenterHoustonTexas77030-

Find similar trials in Boston, MA

By condition
Brain cancer
By specialty
OncologyNeuro-oncology
By research site
Massachusetts General Hospital· Boston, MAMD Anderson Cancer Center· Houston, TX

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