T Cells and TNF (Tumor Necrosis Factor): The Impact of TNF Blockade

Sponsor
Imperial College London
Study ID
NCT01060098
Status
Completed

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 80 Years
Healthy Volunteers
Not accepted

Interventions

Study Details

We aim to translate these findings into patients with rheumatoid arthritis and other conditions treated with anti-TNF (anti-tumor necrosis factor) therapy, such as psoriatic arthritis and ankylosing spondylitis. Patients from rheumatology clinics within NHS (National Health Service) trusts will be recruited. We will correlate disease activity assessed by clinical parameters, ultrasonography, and questionnaires with biomarkers in the blood and target tissues, such as synovium and skin.

Key Dates

Start date
Apr 30, 2010
Status verified
Jan 2020
Primary completion
Dec 31, 2012
Completion
Dec 31, 2012

Study Design

Enrollment
48 participants (actual)

Arms

  • Arm: Rheumatoid arthritis
    Participants with Rheumatoid arthritis
  • Arm: Ankylosing spondylitis
    Participants with Ankylosing spondylitis
  • Arm: Psoriatic arthritis
    Participants with Psoriatic arthritis

Primary Outcome Measure

Measurement of Effector T Helper Type 17 Cells in Peripheral Blood [ Time Frame: Week 0, Week 12 ]

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